{"id":"W2084383393","doi":"10.1186/cc14054","title":"Sphingosine-1 phosphate promotes thymic atrophy during sepsis progression","year":2014,"lang":"en","type":"article","venue":"Critical Care","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Children's Health Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina; Financiadora de Estudos e Projetos; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Japan Society for the Promotion of Science; Russian Foundation for Basic Research; London Health Sciences Centre","keywords":"Sepsis; Sphingosine; Sphingosine-1-phosphate; Medicine; Apoptosis; Immune system; Sphingosine-1-phosphate receptor; T cell; Involution (esoterism); Sphingosine kinase 1; Thymic involution; Endocrinology; Immunology; Internal medicine; Cell biology; Biology; Receptor; Neuroscience; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893868,0.0003018789,0.000339239,0.0003887763,0.0001648001,0.0003053778,0.0001630483,0.0002920993,0.002451398],"category_scores_gemma":[0.0003209665,0.0001360637,0.0002272998,0.0001571218,0.000210044,0.0002790502,0.000369919,0.001132008,0.0005616567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001940762,"about_ca_system_score_gemma":0.000238358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002801947,"about_ca_topic_score_gemma":0.0003726409,"domain_scores_codex":[0.9998652,0.00002756852,0.00001053353,0.00002388044,0.0000342758,0.00003848314],"domain_scores_gemma":[0.999549,0.0000420321,0.0001412189,0.00002664151,0.00005458949,0.0001865402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002508234,0.0001567459,0.002956158,0.0001395913,0.0000129771,0.0005318776,0.00009380625,0.00009492767,0.986928,0.00007713835,0.000323758,0.006176808],"study_design_scores_gemma":[0.0002713417,0.006416744,0.2295446,0.0001345222,0.0001298216,0.003770362,0.0005072913,0.002611729,0.7479181,0.0005517024,0.00809731,0.0000465118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990651,0.006180663,0.001013893,0.00020124,0.00009937014,0.00003900389,0.0004098172,0.0001245045,0.001280557],"genre_scores_gemma":[0.996358,0.001482234,0.0005009433,0.00008204105,0.00004143732,0.00004757109,0.0002880542,0.00001447956,0.001185287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002451398,"threshold_uncertainty_score":0.008200705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007300759879946426,"score_gpt":0.2789381029840921,"score_spread":0.2716373431041456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}