{"id":"W2084403455","doi":"10.1038/sj.leu.2403222","title":"NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration","year":2003,"lang":"en","type":"article","venue":"Leukemia","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":160,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Stem Cell Network","keywords":"Nod; Progenitor cell; Stem cell; Regeneration (biology); Biology; Immunology; Cell biology; Cancer research; In vivo; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005624399,0.001144028,0.000548781,0.001179436,0.0004284575,0.0005794648,0.0004379848,0.000831878,0.004378479],"category_scores_gemma":[0.0002021965,0.0004324138,0.0005135199,0.0003784578,0.0008407251,0.000491258,0.000564526,0.00139634,0.001726749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003777522,"about_ca_system_score_gemma":0.0003741522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003810127,"about_ca_topic_score_gemma":0.0007923273,"domain_scores_codex":[0.9995414,0.00008413618,0.00007084773,0.0001020559,0.0001020099,0.00009956415],"domain_scores_gemma":[0.9995975,0.00006750655,0.0001504399,0.00007471959,0.0000185105,0.00009141913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005091421,0.0001127138,0.0002259004,0.00003570491,0.00001331479,0.0001203733,0.00003128524,0.0001051444,0.9967817,0.0008614048,0.0001285356,0.001074747],"study_design_scores_gemma":[0.00007559922,0.0003173348,0.0008046928,0.000009103527,0.00002509368,0.0004988029,0.00003138563,0.0007045977,0.9937285,0.000177338,0.003621256,0.00000628764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748256,0.0009432262,0.01336905,0.0003397384,0.0001657614,0.0002506505,0.002774008,0.0007695124,0.006562506],"genre_scores_gemma":[0.9598538,0.000810904,0.01724481,0.000199659,0.00004747018,0.0004600064,0.003928569,0.0002357267,0.01721903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004378479,"threshold_uncertainty_score":0.01464742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02018253471301899,"score_gpt":0.2737957799411491,"score_spread":0.2536132452281301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}