{"id":"W2084403455","doi":"10.1038/sj.leu.2403222","title":"NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration","year":2003,"lang":"en","type":"article","venue":"Leukemia","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":160,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Stem Cell Network","keywords":"Nod; Progenitor cell; Stem cell; Regeneration (biology); Biology; Immunology; Cell biology; Cancer research; In vivo; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002117956,0.000335582,0.0002747004,0.0001112238,0.0003940146,0.0001146791,0.0002129817,0.0002440344,0.00002643917],"category_scores_gemma":[0.00002158426,0.0003462944,0.00006123835,0.0001187409,0.0001789963,0.00001370281,0.00008972664,0.000201613,0.0000075034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001229778,"about_ca_system_score_gemma":0.0001415687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003284611,"about_ca_topic_score_gemma":0.0001135397,"domain_scores_codex":[0.9981143,0.0002011049,0.0003178164,0.0007076091,0.0002301263,0.0004290811],"domain_scores_gemma":[0.9989758,0.00001573839,0.00008530218,0.0004527491,0.0001765224,0.0002938735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001732769,0.00006299703,0.0004062628,0.00005085782,0.00004447852,0.000005312471,0.0002775857,0.0001011994,0.9980732,0.0001445623,0.0003798304,0.0002804857],"study_design_scores_gemma":[0.001972469,0.001625997,0.0007023729,0.00002189562,0.00001963551,0.000007389831,0.0001344249,0.00003925127,0.9909248,0.0000221464,0.004126762,0.000402832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975806,0.00060781,0.0001597285,0.00002311964,0.00005743596,0.0009973557,0.0001130437,0.00004173218,0.0004191904],"genre_scores_gemma":[0.997706,0.00002775655,0.0003950932,0.0001441472,0.0001298167,0.0001117019,0.0001640759,0.0000469976,0.001274411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007148327,"threshold_uncertainty_score":0.9998989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02018253471301899,"score_gpt":0.2737957799411491,"score_spread":0.2536132452281301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}