{"id":"W2084425906","doi":"10.1194/jlr.m036566","title":"Inhibition of plasminogen activation by apo(a): role of carboxyl-terminal lysines and identification of inhibitory domains in apo(a)","year":2014,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Canadian Institutes of Health Research","keywords":"Plasmin; Plasminogen activator; Chemistry; Umbilical vein; Receptor; Tissue plasminogen activator; Biochemistry; Internalization; Endothelial stem cell; Kringle domain; Lysine; Cell biology; Molecular biology; Biology; Enzyme; In vitro; Amino acid; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001783067,0.00007662223,0.0002097057,0.0002941789,0.00002991475,0.00000870717,0.000112826,0.0001393965,0.000004652422],"category_scores_gemma":[0.0003381609,0.00006959652,0.00006388147,0.0001748691,0.0001410291,0.00002521622,0.00006969575,0.0001700522,2.766442e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002135244,"about_ca_system_score_gemma":0.0001066061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002749583,"about_ca_topic_score_gemma":0.000005295727,"domain_scores_codex":[0.9983965,0.0002596896,0.0006171402,0.000134733,0.0004522173,0.0001397574],"domain_scores_gemma":[0.9986992,0.00004739701,0.0005085,0.0001551288,0.0005346211,0.00005511445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003003131,0.0001516441,0.001306206,0.0001025572,0.00001878978,4.979397e-7,0.0001299906,0.00001064218,0.9958281,0.00008031071,0.0003160682,0.0017549],"study_design_scores_gemma":[0.000709325,0.0007588922,0.001260033,0.0001551431,0.000008081192,0.00001110389,0.0002763548,0.0001108001,0.9955615,0.0007138079,0.0003791796,0.00005573512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989178,0.000325545,0.0003323503,0.00007652256,0.00005264186,0.0001314007,0.0000110536,7.263906e-7,0.0001519612],"genre_scores_gemma":[0.9992902,0.0001799034,0.000165299,0.000005306377,0.0002967918,0.000004758995,0.00001525011,0.000009629085,0.0000328351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001699165,"threshold_uncertainty_score":0.2838064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01290220469173551,"score_gpt":0.2911026196851226,"score_spread":0.278200414993387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}