{"id":"W2084425906","doi":"10.1194/jlr.m036566","title":"Inhibition of plasminogen activation by apo(a): role of carboxyl-terminal lysines and identification of inhibitory domains in apo(a)","year":2014,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Canadian Institutes of Health Research","keywords":"Plasmin; Plasminogen activator; Chemistry; Umbilical vein; Receptor; Tissue plasminogen activator; Biochemistry; Internalization; Endothelial stem cell; Kringle domain; Lysine; Cell biology; Molecular biology; Biology; Enzyme; In vitro; Amino acid; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002012546,0.0002925358,0.0002860806,0.0001105718,0.0001009417,0.000278959,0.0002776201,0.0002908497,0.0004487299],"category_scores_gemma":[0.0001253477,0.000108539,0.0002254492,0.0001026297,0.0003115471,0.0001709173,0.0001183791,0.0003944963,0.0002304727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002767103,"about_ca_system_score_gemma":0.0001686039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005909232,"about_ca_topic_score_gemma":0.0004115351,"domain_scores_codex":[0.999873,0.00002366324,0.00001305192,0.00002235282,0.00002845504,0.00003931532],"domain_scores_gemma":[0.9998852,0.00002568941,0.00003589292,0.00001334586,0.000016842,0.0000231013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002986468,0.00006312921,0.0002352093,0.00004900746,0.000006015848,0.00002543019,0.000006980936,0.00004745334,0.9974163,0.00004550792,0.00001202469,0.001794289],"study_design_scores_gemma":[0.00002400212,0.0006770743,0.007010209,0.000005016123,0.00001813224,0.000278449,0.000007561107,0.0004627815,0.9905398,0.00002281792,0.0009500632,0.000004136157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932896,0.004657944,0.001277234,0.00004255397,0.000009169948,0.00001612221,0.0000798857,0.00001504975,0.0006125837],"genre_scores_gemma":[0.9957386,0.001661037,0.001477083,0.00003244679,0.00001074412,0.00001712548,0.0001631874,0.000006520936,0.0008932409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005909232,"threshold_uncertainty_score":0.002007723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01290220469173551,"score_gpt":0.2911026196851226,"score_spread":0.278200414993387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}