{"id":"W2084431173","doi":"10.1016/j.brainresbull.2014.01.006","title":"High-energy compounds mobilize intracellular Ca2+ and activate calpain in cultured cells: Is calpain an energy-dependent protease?","year":2014,"lang":"en","type":"article","venue":"Brain Research Bulletin","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Atlantic Canada Opportunities Agency; U.S. Department of Veterans Affairs","keywords":"Calpain; Intracellular; Extracellular; Cell biology; Biology; Neuroprotection; Biochemistry; Calcium in biology; Bioenergetics; Chemistry; Pharmacology; Enzyme; Mitochondrion","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003151706,0.0002838341,0.0002687957,0.0002140014,0.0002694982,0.0001316859,0.0002877362,0.0004193769,0.0002728589],"category_scores_gemma":[0.0004482534,0.0002583314,0.00007782771,0.0002110121,0.0003145574,0.00000767549,0.0002554372,0.0003698355,0.00001773961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008742121,"about_ca_system_score_gemma":0.0001006324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003016478,"about_ca_topic_score_gemma":0.0006836945,"domain_scores_codex":[0.9952841,0.002195321,0.0003733798,0.0009059841,0.0005939782,0.0006471868],"domain_scores_gemma":[0.9985802,0.0001492136,0.00008754018,0.0006105533,0.0002022101,0.0003702795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005324836,0.0003279076,0.0001175527,0.00005302091,0.00003314042,0.00001733343,0.0001195708,0.000140792,0.9128826,0.002937061,0.07417472,0.008663767],"study_design_scores_gemma":[0.001492676,0.0005663861,0.0002353014,0.00003852188,0.000004210822,0.0000130067,0.0002062292,0.001907435,0.4255889,0.001127033,0.5684937,0.0003266488],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9228403,0.001569445,0.04545929,0.02582805,0.0003707466,0.001886284,0.00008367591,0.0001374702,0.001824767],"genre_scores_gemma":[0.9811347,0.0001538901,0.001030733,0.001313235,0.000453445,0.000316709,0.0002881791,0.00005764732,0.01525151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.494319,"threshold_uncertainty_score":0.9999869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0144554819332745,"score_gpt":0.2687254074936222,"score_spread":0.2542699255603477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}