{"id":"W2084462172","doi":"10.1016/j.cub.2014.06.009","title":"Ancient Endo-siRNA Pathways Reveal New Tricks","year":2014,"lang":"en","type":"review","venue":"Current Biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Argonaute; Biology; Trans-acting siRNA; Small interfering RNA; RNA interference; RNA-induced silencing complex; Effector; Small RNA; RNA silencing; Gene silencing; Computational biology; RNA; RasiRNA; Dicer; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002504805,0.000578833,0.001298204,0.0001533147,0.00006883508,0.00002605946,0.000751699,0.0007507686,0.00006590106],"category_scores_gemma":[0.0001459221,0.0004478402,0.0007772995,0.0001479818,0.0001126931,0.000002033465,0.0003600035,0.000404726,0.0004901911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004161658,"about_ca_system_score_gemma":0.0005785686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001071896,"about_ca_topic_score_gemma":0.00000604698,"domain_scores_codex":[0.9973668,0.0002856863,0.0007029294,0.0009665776,0.00009161443,0.0005863539],"domain_scores_gemma":[0.9984251,0.00003755159,0.0004259709,0.0007930139,0.0000821931,0.00023616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000009617829,0.00004339901,0.00001440286,0.0009711937,0.00008923067,0.00000165734,0.000006577263,1.056028e-7,0.0005767763,0.0001142526,0.05698952,0.9411833],"study_design_scores_gemma":[0.0002384306,0.0004682913,0.00000290448,0.0009981169,0.0001868671,0.00004610414,0.000002159056,7.809978e-7,0.0002383265,0.00007369005,0.9972534,0.0004909422],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001976737,0.9939204,0.001405004,0.00001093742,0.00303369,0.000444032,0.0001592635,0.00002456928,0.0008043629],"genre_scores_gemma":[0.0001853098,0.9930213,0.00006771937,0.0001264628,0.002644249,0.00007531806,0.002851966,0.0000468444,0.0009808359],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9406923,"threshold_uncertainty_score":0.9997973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0869194340627727,"score_gpt":0.3612960460302269,"score_spread":0.2743766119674542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}