{"id":"W2084468220","doi":"10.1155/2011/164197","title":"AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone","year":2011,"lang":"en","type":"article","venue":"Biochemistry Research International","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal General Hospital; McMaster University; Hamilton Health Sciences; Juravinski Cancer Centre","funders":"Canadian Institutes of Health Research; McMaster University","keywords":"Stromal cell; RUNX2; Transcription factor; Gene knockdown; Matrix metalloproteinase; Cancer research; Stromal cell-derived factor 1; Cell; Giant-cell tumor of bone; Cell biology; Regulator; Biology; Cell culture; Medicine; Pathology; Immunology; Gene; Chemokine; CXCR4; Inflammation; Giant cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001900281,0.0003271573,0.0002441993,0.0003458155,0.0002459384,0.0003720534,0.0002086363,0.0003104027,0.002531182],"category_scores_gemma":[0.0002147432,0.0001927265,0.0002922729,0.0002107128,0.0003185542,0.0002395779,0.0002049895,0.0005725662,0.0008402991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002844154,"about_ca_system_score_gemma":0.0002224397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004517744,"about_ca_topic_score_gemma":0.0005505557,"domain_scores_codex":[0.9998282,0.00003317863,0.00001566178,0.00003433361,0.00005493244,0.00003370452],"domain_scores_gemma":[0.9998079,0.00005670476,0.00003274533,0.0000226817,0.00004053176,0.00003941009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001181901,0.00001573476,0.0002205281,0.00004070609,0.000002131553,0.0001049346,0.0000220845,0.00001768616,0.9985752,0.00008164407,0.00003481441,0.0007662973],"study_design_scores_gemma":[0.00002314394,0.0001301779,0.006439366,0.000007415938,0.00001750964,0.0007098599,0.00007035161,0.0008643749,0.9895278,0.0001095079,0.002096849,0.000003706104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863455,0.005448766,0.005305912,0.0003239337,0.00007582279,0.00002817888,0.0003761561,0.0001059593,0.001989891],"genre_scores_gemma":[0.9914579,0.001350203,0.002585327,0.0001059414,0.00002059697,0.00003894582,0.0005095166,0.00002364408,0.003907969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002531182,"threshold_uncertainty_score":0.008467615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06632833134439035,"score_gpt":0.348142092162095,"score_spread":0.2818137608177046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}