{"id":"W2084468220","doi":"10.1155/2011/164197","title":"AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone","year":2011,"lang":"en","type":"article","venue":"Biochemistry Research International","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal General Hospital; McMaster University; Hamilton Health Sciences; Juravinski Cancer Centre","funders":"Canadian Institutes of Health Research; McMaster University","keywords":"Stromal cell; RUNX2; Transcription factor; Gene knockdown; Matrix metalloproteinase; Cancer research; Stromal cell-derived factor 1; Cell; Giant-cell tumor of bone; Cell biology; Regulator; Biology; Cell culture; Medicine; Pathology; Immunology; Gene; Chemokine; CXCR4; Inflammation; Giant cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005462762,0.00008870487,0.0002128573,0.0001226371,0.0000139789,0.000004164388,0.0002727566,0.00004783153,0.000675139],"category_scores_gemma":[0.0001920453,0.00006387806,0.0001021664,0.0001724155,0.0002421156,0.00002616032,0.00009496627,0.0001870005,0.00001065117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000602525,"about_ca_system_score_gemma":0.0002316575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005428023,"about_ca_topic_score_gemma":0.000005478878,"domain_scores_codex":[0.9983104,0.00004700167,0.0003799232,0.0001861813,0.0008923587,0.000184082],"domain_scores_gemma":[0.9989544,0.0001122961,0.0001634481,0.0003176395,0.0003812434,0.00007093833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006884047,0.003906327,0.08442047,0.0004024285,0.0000716045,0.0001942125,0.0005365133,3.221334e-7,0.9074607,0.0002627996,0.001850478,0.0002056823],"study_design_scores_gemma":[0.001422697,0.0003575404,0.1164894,0.0001708005,0.00001369372,0.00003381087,0.0005203641,0.00003193083,0.8807074,0.000119931,0.0000933659,0.00003904398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9666663,0.0003429326,8.164936e-7,0.0002231764,0.00002897217,0.000196844,0.00008219357,0.000002805236,0.03245592],"genre_scores_gemma":[0.9978204,0.00003287974,0.0003386123,0.00001263442,0.00004744341,0.00003395602,0.00003725327,0.00000936485,0.001667464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03206895,"threshold_uncertainty_score":0.7392298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06632833134439035,"score_gpt":0.348142092162095,"score_spread":0.2818137608177046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}