{"id":"W2084494110","doi":"10.1128/mbio.02180-14","title":"Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″)-Ia","year":2015,"lang":"en","type":"article","venue":"mBio","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Ontario Genomics; University of Toronto; McMaster University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Public Health Service","keywords":"ANT; Tobramycin; Adenylylation; Aminoglycoside; Chemistry; Nucleotidyltransferase; Nucleoside; Biochemistry; Biology; Enzyme; Stereochemistry; Antibiotics; RNA; Gentamicin; Gene; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006175799,0.000229663,0.0001789043,0.0001362199,0.0001248742,0.0002881981,0.0002959577,0.0003831942,0.0004392913],"category_scores_gemma":[0.00009021774,0.000129191,0.0002236171,0.0001024761,0.0002121866,0.0001463467,0.0002000022,0.0003446437,0.0002662186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003340438,"about_ca_system_score_gemma":0.0001769148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005069139,"about_ca_topic_score_gemma":0.0003106087,"domain_scores_codex":[0.9999357,0.000008013873,0.000006532043,0.00001700635,0.00001819181,0.00001439335],"domain_scores_gemma":[0.9999411,0.000007887994,0.00002395134,0.000005486134,0.000006814061,0.00001478138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001197352,0.00002960657,0.0008508913,0.00002739403,0.000005720172,0.0003015935,0.0000231198,0.0008869709,0.9950871,0.0009519399,0.00005525841,0.001660688],"study_design_scores_gemma":[0.00008136074,0.0006551528,0.02691173,0.00002024215,0.00004369079,0.00298301,0.0001730141,0.03540406,0.922832,0.001819454,0.009038738,0.0000375709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939669,0.001217593,0.002679432,0.0001319245,0.0000191546,0.00001843088,0.00008518234,0.00007742579,0.001803918],"genre_scores_gemma":[0.9975539,0.0004272364,0.001191433,0.0000362508,0.000007592575,0.000007676756,0.0002374815,0.000008355609,0.0005301708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005069139,"threshold_uncertainty_score":0.002423644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124559299639044,"score_gpt":0.2631343358389855,"score_spread":0.2506784058750812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}