{"id":"W2084494110","doi":"10.1128/mbio.02180-14","title":"Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″)-Ia","year":2015,"lang":"en","type":"article","venue":"mBio","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Ontario Genomics; University of Toronto; McMaster University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Public Health Service","keywords":"ANT; Tobramycin; Adenylylation; Aminoglycoside; Chemistry; Nucleotidyltransferase; Nucleoside; Biochemistry; Biology; Enzyme; Stereochemistry; Antibiotics; RNA; Gentamicin; Gene; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001837703,0.0001991582,0.0001691296,0.00002089627,0.0001102662,0.00008088489,0.0002680562,0.0001309485,0.000003915085],"category_scores_gemma":[0.0002300493,0.0001558746,0.00006186703,0.00008558278,0.000150006,0.000005573652,0.00007040709,0.00006563246,0.000003856398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002298762,"about_ca_system_score_gemma":0.00005778514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001472021,"about_ca_topic_score_gemma":0.00007931952,"domain_scores_codex":[0.998858,0.00005085153,0.0002059507,0.0004184735,0.0001471554,0.0003195827],"domain_scores_gemma":[0.9991815,0.00002646858,0.00004730767,0.000452279,0.0001155273,0.0001769175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000364147,0.00001610555,0.006003021,0.00003674063,0.00005012215,0.000005933995,0.00009654271,0.000005365486,0.9564011,0.0003794629,0.0361761,0.0004653918],"study_design_scores_gemma":[0.0007132784,0.0002634321,0.006250325,0.00003394723,0.00004443046,0.0000169952,0.0001788261,0.00003264731,0.9267848,0.0002003327,0.06513048,0.000350565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894663,0.001292062,0.00686296,0.001171221,0.0001924314,0.0004597912,0.0002257151,0.00001427361,0.0003152405],"genre_scores_gemma":[0.9924519,0.0000461505,0.004886801,0.001022473,0.0001223196,0.000003611849,0.00009184051,0.00003499234,0.001339918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02961633,"threshold_uncertainty_score":0.6356381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124559299639044,"score_gpt":0.2631343358389855,"score_spread":0.2506784058750812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}