{"id":"W2084518991","doi":"10.1002/cbic.201100617","title":"Kinetic Capillary Electrophoresis with Mass‐Spectrometry Detection (KCE‐MS) Facilitates Label‐Free Solution‐Based Kinetic Analysis of Protein–Small Molecule Binding","year":2011,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Microfluidic and Capillary Electrophoresis Applications","field":"Engineering","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Capillary electrophoresis; Small molecule; Mass spectrometry; Tandem; Tandem mass spectrometry; Chromatography; Kinetics; Combinatorial chemistry; Chemistry; Computational biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00128883,0.0008517084,0.0007081216,0.0008201692,0.00045807,0.001183068,0.001343841,0.00139431,0.001088321],"category_scores_gemma":[0.001403313,0.0005623432,0.0003579232,0.0004641115,0.0008900164,0.001404202,0.0008590791,0.001325268,0.001147173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006455778,"about_ca_system_score_gemma":0.001035226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000799872,"about_ca_topic_score_gemma":0.001365857,"domain_scores_codex":[0.9989914,0.0001347802,0.00005500772,0.0002460702,0.0004777923,0.00009496635],"domain_scores_gemma":[0.9989128,0.0004573344,0.0001888586,0.000118561,0.0002256748,0.00009683252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007014239,0.00003241964,0.0002847393,0.0001615426,0.000009946123,0.00005028598,0.00002522346,0.0001870221,0.9822458,0.002230233,0.0005180199,0.01418464],"study_design_scores_gemma":[0.000008776088,0.00005650795,0.0003941357,0.00000785496,0.000009142222,0.0003735316,0.000008569857,0.00613293,0.9870993,0.0003711468,0.005511896,0.00002605201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2536463,0.01448199,0.7158779,0.001736281,0.0008420333,0.0003575053,0.001014046,0.004576181,0.0074677],"genre_scores_gemma":[0.4914951,0.009510015,0.4865012,0.0006848082,0.0002276668,0.0003171066,0.0008195217,0.0003351841,0.01010932],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.00139431,"threshold_uncertainty_score":0.006816089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086920969149659,"score_gpt":0.1808760505971249,"score_spread":0.1700068409056284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}