{"id":"W2084522014","doi":"10.1007/s10549-013-2489-y","title":"Phosphorylation of AKT pathway proteins is not predictive of benefit of taxane therapy in early breast cancer","year":2013,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research; Ontario Institute for Cancer Research","funders":"National Institute for Health and Care Research; Cancer Research UK; Ontario Institute for Cancer Research","keywords":"Taxane; Tact; Docetaxel; Epirubicin; Oncology; Medicine; Breast cancer; Anthracycline; Internal medicine; Chemotherapy; Cancer; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000745799,0.0002210681,0.000496061,0.0004080449,0.0001985123,0.0005517064,0.0002251933,0.0004588618,0.00159061],"category_scores_gemma":[0.002096757,0.0001290413,0.0003518832,0.0003302661,0.0002544355,0.0003787188,0.0001706312,0.0006714323,0.0002210376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003671516,"about_ca_system_score_gemma":0.0003191366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007352424,"about_ca_topic_score_gemma":0.002302296,"domain_scores_codex":[0.9997522,0.00007019538,0.00002578879,0.00002807838,0.00005909308,0.00006460932],"domain_scores_gemma":[0.9987078,0.0005591036,0.0003229616,0.00007397978,0.00008153803,0.0002545505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009005501,0.0002816698,0.937961,0.00009166839,0.0001490612,0.0006782006,0.00005917304,0.0006506778,0.02024917,0.0001308756,0.0004346971,0.03030827],"study_design_scores_gemma":[0.00006065841,0.0007484577,0.9928926,0.00001976765,0.0001211598,0.00126261,0.00007965342,0.0007985213,0.00294425,0.0002844653,0.0007812184,0.000006643203],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960583,0.002016713,0.0001421042,0.0001866345,0.00002994493,0.000007473521,0.0001480907,0.000007913699,0.001402825],"genre_scores_gemma":[0.9992145,0.0002612835,0.00007344109,0.00003701761,0.00001656079,0.000002341716,0.000124016,0.000001727301,0.0002691025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00159061,"threshold_uncertainty_score":0.005321145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02726780882715448,"score_gpt":0.3107653741352789,"score_spread":0.2834975653081244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}