{"id":"W2084523291","doi":"10.1016/j.bpj.2013.11.1844","title":"Calcium Signaling in Muscle Cells from a Patient Cohort with Inheritable Muscle Diseases","year":2014,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"RYR1; Myogenesis; Ryanodine receptor; Malignant hyperthermia; Calcium signaling; Phenotype; Calcium; Calcium channel; Myocyte; Voltage-dependent calcium channel; Internal medicine; Endocrinology; Biology; Medicine; Chemistry; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001802865,0.0005365466,0.0004298019,0.0008690871,0.0009440059,0.0008278579,0.000431629,0.0006345749,0.00249248],"category_scores_gemma":[0.001310785,0.0002312772,0.0002510773,0.0006278809,0.0003876174,0.0003239046,0.0005029313,0.0004646677,0.0004380218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002141939,"about_ca_system_score_gemma":0.0001967193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001896958,"about_ca_topic_score_gemma":0.001358442,"domain_scores_codex":[0.9997918,0.00002110789,0.00002712768,0.0000711516,0.0000505986,0.00003814112],"domain_scores_gemma":[0.9996461,0.00009900606,0.00007084198,0.00003120386,0.00005989778,0.00009301104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001047698,0.0001496861,0.8799376,0.00003771859,0.00008138944,0.06052743,0.001200824,0.0002147392,0.04877875,0.0002662152,0.0009405349,0.006817379],"study_design_scores_gemma":[0.00004484219,0.0004451844,0.8432453,0.00002518263,0.0001096052,0.1470268,0.001684692,0.0007209082,0.004643959,0.0003197972,0.001707137,0.00002652655],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999096,0.000101984,0.00009542636,0.00009153943,0.000006389412,0.000003454546,0.0001942829,0.000006700077,0.0004042177],"genre_scores_gemma":[0.9992402,0.00009172865,0.00007547256,0.00005727114,0.00001903242,0.000003575704,0.0002691423,0.000005364634,0.0002382843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00249248,"threshold_uncertainty_score":0.008338213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008312809246574663,"score_gpt":0.2113073240221603,"score_spread":0.2029945147755857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}