{"id":"W2084543934","doi":"10.1002/1097-0215(20010520)95:3<189::aid-ijc1032>3.0.co;2-n","title":"FounderBRCA1 andBRCA2 mutations in early-onset French Canadian breast cancer cases unselected for family history","year":2001,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôtel-Dieu de Montréal; Jewish General Hospital; Montreal General Hospital; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"Medical Research Council; Medical Research Council Canada; Cancer Research Society","keywords":"Breast cancer; Family history; Ovarian cancer; Medicine; Invasive lobular carcinoma; Cancer; Oncology; Lobular carcinoma; Germline mutation; First-degree relatives; Founder effect; Ductal carcinoma; Internal medicine; Mutation; Invasive ductal carcinoma; Biology; Genetics; Genotype; Gene; Haplotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003715354,0.0005972352,0.0003787274,0.002570773,0.002623057,0.0007005555,0.0005556647,0.0006435163,0.002219538],"category_scores_gemma":[0.00228012,0.000442562,0.0003859578,0.001808021,0.000888954,0.0001824289,0.0004922684,0.0004031864,0.0002247181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005693158,"about_ca_system_score_gemma":0.005301923,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8663577,"about_ca_topic_score_gemma":0.8910269,"domain_scores_codex":[0.9993092,0.00004407432,0.00003353541,0.0001190027,0.0002287502,0.000265385],"domain_scores_gemma":[0.9989789,0.0001587627,0.000240642,0.00006355214,0.0003382109,0.0002199591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001275609,0.00002582226,0.9832392,0.00003754244,0.00003883662,0.006073146,0.001149096,0.000103755,0.001773454,0.00006086908,0.0006485876,0.006722107],"study_design_scores_gemma":[0.00001280854,0.00005590454,0.9831261,0.0000214475,0.00003865089,0.01373438,0.001017908,0.0001536158,0.0003686703,0.00002831532,0.001422273,0.00001993954],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975833,0.0008220836,0.0000713733,0.0000791393,0.000008831587,0.00001624866,0.0003207102,0.000008012072,0.001090367],"genre_scores_gemma":[0.9982881,0.0006432656,0.0001178587,0.00006278363,0.00001102462,0.000007353725,0.0003547047,0.000003711598,0.0005111329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1336423,"threshold_uncertainty_score":0.2688587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.019946869387255,"score_gpt":0.3075977131015379,"score_spread":0.2876508437142829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}