{"id":"W2084544097","doi":"10.1515/bc.2006.030","title":"Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH","year":2006,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"National Cancer Institute","keywords":"Caveolae; Cathepsin B; Cathepsin L; Cathepsin D; Cell biology; Myocyte; Chemistry; Western blot; Cathepsin; Molecular biology; Caveolin; Biology; Biochemistry; Signal transduction; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006717074,0.0002276652,0.0003017822,0.00001707025,0.00006444078,0.000006442115,0.0001786902,0.0004382405,0.0001194376],"category_scores_gemma":[0.00009086203,0.0001747343,0.00007756858,0.0000829842,0.0002344481,0.000004696702,0.0002475275,0.0001217126,0.000002260442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001923147,"about_ca_system_score_gemma":0.0000171404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000495781,"about_ca_topic_score_gemma":0.00005567547,"domain_scores_codex":[0.9987304,0.00005591267,0.0002686065,0.0005545557,0.00007064945,0.0003198354],"domain_scores_gemma":[0.9994934,0.00003455414,0.00009958682,0.0002250467,0.00004252024,0.0001049225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006821995,0.0001651143,0.01267101,0.00003633849,0.00001485734,0.000001631886,0.00004167961,0.00002921356,0.9858212,0.00001048134,0.0000894943,0.0004367071],"study_design_scores_gemma":[0.0006455184,0.0003546267,0.1198422,0.00001295352,0.00000548693,0.00000370359,0.00008859966,0.0001241346,0.8783252,0.0002304877,0.0001479718,0.0002190902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990979,0.0001230863,0.00002343493,0.00004756205,0.00001660697,0.0001396109,0.00007157512,0.00001537722,0.0004648821],"genre_scores_gemma":[0.9990365,0.00004510485,0.0001179841,0.00017126,0.00008574971,0.00003178731,0.0004262817,0.000009987357,0.00007538173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1074961,"threshold_uncertainty_score":0.7125458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01305681569717521,"score_gpt":0.2402912919358327,"score_spread":0.2272344762386575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}