{"id":"W2084545410","doi":"10.1038/nrg2317","title":"The ethics of human gene transfer","year":2008,"lang":"en","type":"review","venue":"Nature Reviews Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"U.S. Food and Drug Administration","keywords":"Biology; Context (archaeology); Gene transfer; Germline; Character (mathematics); Engineering ethics; Face (sociological concept); Field (mathematics); Genetics; Computational biology; Gene; Biotechnology; Sociology; Social science; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.000608338,0.0005787032,0.001407927,0.00006096295,0.0002220916,0.00001955445,0.0008529138,0.002065507,0.000006084628],"category_scores_gemma":[0.0002086942,0.0003761754,0.001148221,0.0002465942,0.0001760155,8.156222e-7,0.000139868,0.001734264,0.0000112989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001898423,"about_ca_system_score_gemma":0.0002607169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.64459e-7,"about_ca_topic_score_gemma":0.00001639639,"domain_scores_codex":[0.9973438,0.0003791216,0.001085619,0.0005131981,0.00030762,0.0003706675],"domain_scores_gemma":[0.9981584,0.00008950576,0.0002334585,0.001265152,0.0001488065,0.0001047067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002080046,0.00002624075,9.16933e-7,0.007427074,0.0001874592,0.000003591655,0.00003042534,0.000005744264,0.001545331,0.00008240566,0.003922357,0.9867664],"study_design_scores_gemma":[0.00008908661,0.0001149396,0.000001445995,0.001754351,0.000353039,0.0001288502,0.000001853188,6.832664e-7,0.003109863,0.000007965409,0.9940556,0.0003822802],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000009637693,0.9972442,0.0009107277,0.00001861633,0.0004302412,0.001008919,0.00005087422,0.000008949731,0.0003178378],"genre_scores_gemma":[0.00002273014,0.9975833,0.0007242772,0.00006894545,0.0007051969,0.00008904836,0.000281966,0.0001041301,0.0004203821],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9901333,"threshold_uncertainty_score":0.999869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04266351589150989,"score_gpt":0.4205801533607986,"score_spread":0.3779166374692887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}