{"id":"W2084559524","doi":"10.1016/j.ab.2007.08.014","title":"High-affinity binding measurements of antibodies to cell-surface-expressed antigens","year":2007,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"Antigen; Avidity; Antibody; Chemistry; Molecular biology; Cell; Cell membrane; Dissociation constant; Biochemistry; Biology; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005667077,0.0005767379,0.0004471524,0.000511505,0.0006703294,0.0007733248,0.0008428825,0.0007869449,0.001851018],"category_scores_gemma":[0.0009437383,0.000371517,0.0002806923,0.0006572091,0.0003674598,0.0004785408,0.0004370662,0.001597923,0.001248163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009014051,"about_ca_system_score_gemma":0.0003605765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002552989,"about_ca_topic_score_gemma":0.004329247,"domain_scores_codex":[0.9993134,0.0001383936,0.00002989298,0.0001160211,0.0002055158,0.0001968114],"domain_scores_gemma":[0.9993541,0.0002519684,0.00004278488,0.00006008897,0.0001738291,0.000117337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007143088,0.00004634057,0.0001967093,0.0000373857,0.000007686644,0.0000133723,0.00003386923,0.0000673475,0.9978389,0.0001829011,0.0000841107,0.001419771],"study_design_scores_gemma":[0.00001070695,0.00008165275,0.003365751,0.000004938729,0.00001396502,0.0000586277,0.00003469719,0.001800838,0.9935649,0.0001319059,0.0009256252,0.000006372165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8974649,0.003183548,0.09241374,0.0002308176,0.0001011343,0.0000999072,0.0003679798,0.0003076798,0.005830301],"genre_scores_gemma":[0.9478267,0.002320816,0.03823391,0.0003288119,0.00004837891,0.000159919,0.001082749,0.00009702388,0.009901657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002552989,"threshold_uncertainty_score":0.006540179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04999411634134793,"score_gpt":0.3412507182514956,"score_spread":0.2912566019101476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}