{"id":"W2084559524","doi":"10.1016/j.ab.2007.08.014","title":"High-affinity binding measurements of antibodies to cell-surface-expressed antigens","year":2007,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Amgen (Canada)","funders":"","keywords":"Antigen; Avidity; Antibody; Chemistry; Molecular biology; Cell; Cell membrane; Dissociation constant; Biochemistry; Biology; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005981775,0.0002136316,0.0004607548,0.00009582885,0.00008996561,0.00001556218,0.0002036499,0.0001597933,0.0003793553],"category_scores_gemma":[0.0003079517,0.0001777211,0.0001909248,0.0004266386,0.0001894295,0.00002762502,0.0001552913,0.0002651686,0.0001440956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006537446,"about_ca_system_score_gemma":0.0001182462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001307311,"about_ca_topic_score_gemma":0.00000335142,"domain_scores_codex":[0.9977221,0.00001781006,0.000465611,0.0003848772,0.0008421383,0.0005673908],"domain_scores_gemma":[0.9985601,0.0001547697,0.00007573257,0.0003661861,0.0003081151,0.0005350498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004264159,0.0003093939,0.1018317,0.0003225401,0.0001201656,0.0000605043,0.00003334994,0.00000600971,0.8937393,0.00002220415,0.002875264,0.0002531858],"study_design_scores_gemma":[0.0005294899,0.0001511715,0.02308137,0.0001290627,0.00007683192,0.000008567582,0.00008276232,0.00003003086,0.9751769,0.00001509286,0.0005426064,0.0001760774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832175,0.0001433615,0.0001217131,0.000822221,0.00005684422,0.0001525947,0.00005113927,0.00003143364,0.01540313],"genre_scores_gemma":[0.9904789,0.00003859853,0.004104205,0.0001965701,0.0001554324,9.472777e-7,0.0000585483,0.00001781285,0.004949031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08143768,"threshold_uncertainty_score":0.7247256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04999411634134793,"score_gpt":0.3412507182514956,"score_spread":0.2912566019101476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}