{"id":"W2084574319","doi":"10.1042/bj20071136","title":"Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells","year":2008,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"LNCaP; Glucuronidation; Farnesoid X receptor; Prostate cancer; Androsterone; Androgen receptor; Endocrinology; Internal medicine; Androgen; Dihydrotestosterone; Chemistry; Glucuronosyltransferase; Cancer research; Nuclear receptor; Biology; Cancer; Medicine; Biochemistry; Transcription factor; Enzyme; Microsome; Steroid; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001130888,0.0002564755,0.0003226155,0.0002156848,0.000180987,0.0003080451,0.0001306825,0.000133003,0.002978778],"category_scores_gemma":[0.00007820129,0.0001175386,0.0002792378,0.0002693374,0.0001354959,0.00009617209,0.0001426888,0.0003529986,0.000914897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002327585,"about_ca_system_score_gemma":0.0003385415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001763356,"about_ca_topic_score_gemma":0.001859352,"domain_scores_codex":[0.9998187,0.00003927605,0.00001261985,0.00002876711,0.00005980013,0.00004072131],"domain_scores_gemma":[0.9999529,0.00001084577,0.00000715342,0.000007556923,0.00001029097,0.00001124196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001714886,0.00006672154,0.0003225712,0.00006670989,0.000009358043,0.0001088878,0.0000363515,0.0000741234,0.9958182,0.0001467914,0.0003644493,0.002814213],"study_design_scores_gemma":[0.00002410672,0.0004744015,0.006819008,0.000005616359,0.0000259028,0.0004117767,0.00006216206,0.0007066344,0.9786997,0.00005038481,0.01271236,0.000007830847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975598,0.009504731,0.004318256,0.0004693985,0.0001378238,0.00005741701,0.001491509,0.0004170557,0.008005735],"genre_scores_gemma":[0.966529,0.004713476,0.002223853,0.000210279,0.00002995426,0.00006526515,0.002638947,0.00004268201,0.02354645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002978778,"threshold_uncertainty_score":0.009965003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304520438852913,"score_gpt":0.2489078673899167,"score_spread":0.2358626630013875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}