{"id":"W2084577762","doi":"10.1371/journal.ppat.1000753","title":"Reverse Genetics in Candida albicans Predicts ARF Cycling Is Essential for Drug Resistance and Virulence","year":2010,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Biotechnology Research Institute; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Candida albicans; Fluconazole; Biology; Corpus albicans; Antifungal drug; Microbiology; Virulence; Fungal protein; Virulence factor; Caspofungin; Aspergillus fumigatus; Drug resistance; Mutant; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002917709,0.0004822446,0.0003523724,0.0004596892,0.0002422677,0.0005906372,0.0003548964,0.0005275657,0.002426089],"category_scores_gemma":[0.0002789962,0.0002447074,0.0005760533,0.0003767515,0.0002780904,0.0001875249,0.0003523004,0.001090726,0.001022171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000452506,"about_ca_system_score_gemma":0.0004179123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001076523,"about_ca_topic_score_gemma":0.00161332,"domain_scores_codex":[0.9996812,0.00003955612,0.00004076742,0.00006654322,0.0001295721,0.00004237702],"domain_scores_gemma":[0.9997433,0.00008406935,0.00006066044,0.00004434167,0.00003656809,0.0000310281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007034351,0.00001995788,0.0002313229,0.00003056569,0.000003805172,0.00006778244,0.000007654427,0.00009512767,0.9969648,0.0002543188,0.00008544927,0.00216882],"study_design_scores_gemma":[0.00002344481,0.0001769284,0.007482654,0.00002172963,0.00003805671,0.000870693,0.00005575249,0.003375069,0.9744119,0.0004277271,0.01309228,0.00002369302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9535086,0.002870861,0.02861246,0.0006341104,0.000267664,0.0002062113,0.004720819,0.001354464,0.007824766],"genre_scores_gemma":[0.9710128,0.001853528,0.01705387,0.0003035394,0.0000251287,0.0001082311,0.003721534,0.0002982026,0.005623168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002426089,"threshold_uncertainty_score":0.008116066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286125113906814,"score_gpt":0.2696157386198597,"score_spread":0.2567544874807915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}