{"id":"W2084577762","doi":"10.1371/journal.ppat.1000753","title":"Reverse Genetics in Candida albicans Predicts ARF Cycling Is Essential for Drug Resistance and Virulence","year":2010,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Biotechnology Research Institute; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Candida albicans; Fluconazole; Biology; Corpus albicans; Antifungal drug; Microbiology; Virulence; Fungal protein; Virulence factor; Caspofungin; Aspergillus fumigatus; Drug resistance; Mutant; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002898675,0.0001639799,0.000313915,0.0000673313,0.0001059609,0.00001881436,0.00009451978,0.0001244157,0.00008062521],"category_scores_gemma":[0.0004228898,0.0001550248,0.00007736365,0.0001398396,0.0001719552,0.00006033097,0.00003720168,0.000301056,0.000006514565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000036012,"about_ca_system_score_gemma":0.0001476478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004634287,"about_ca_topic_score_gemma":0.004939734,"domain_scores_codex":[0.9985642,0.00002701003,0.0003198968,0.000476881,0.0002607281,0.000351225],"domain_scores_gemma":[0.9990459,0.0001360927,0.00008007136,0.0004299813,0.0001221079,0.0001858489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000471739,0.0001990792,0.3699125,0.0004563891,0.00003150574,0.00007008782,0.001593573,7.896092e-7,0.6252908,0.0001002639,0.001209346,0.0006639487],"study_design_scores_gemma":[0.006425947,0.0002733061,0.7521296,0.001216023,0.0006796308,0.00002462446,0.001362111,0.003791952,0.2137458,0.001917258,0.01743265,0.001001129],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996975,0.0004280196,0.0002462667,0.0007981418,0.0001452945,0.0006320454,0.0002088701,0.00003289683,0.0005334437],"genre_scores_gemma":[0.9909788,0.0003949775,0.006085065,0.0004623041,0.0001989908,0.00004063264,0.00001979127,0.00002613091,0.001793334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.411545,"threshold_uncertainty_score":0.6321726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286125113906814,"score_gpt":0.2696157386198597,"score_spread":0.2567544874807915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}