{"id":"W2084590452","doi":"10.1021/ja028212e","title":"Nonequilibrium Capillary Electrophoresis of Equilibrium Mixtures − A Single Experiment Reveals Equilibrium and Kinetic Parameters of Protein−DNA Interactions","year":2002,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Microfluidic and Capillary Electrophoresis Applications","field":"Engineering","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"Electropherogram; Chemistry; Capillary electrophoresis; Equilibrium constant; Electrophoresis; Binding constant; Macromolecule; Non-equilibrium thermodynamics; DNA; Reaction rate constant; Oligonucleotide; Thermodynamics; Kinetics; Analytical Chemistry (journal); Chromatography; Physical chemistry; Binding site; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009070413,0.0008251133,0.001018624,0.0009525162,0.0003632591,0.0009314052,0.001144726,0.0009828246,0.0008584911],"category_scores_gemma":[0.001457577,0.0006008352,0.0002837126,0.0004450207,0.0004336065,0.001041005,0.0004436443,0.001405379,0.0004022878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006528196,"about_ca_system_score_gemma":0.000423948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000803193,"about_ca_topic_score_gemma":0.001403992,"domain_scores_codex":[0.9992195,0.00008703335,0.00003658701,0.0003310637,0.0002573583,0.00006832304],"domain_scores_gemma":[0.9987914,0.0006143069,0.0001407066,0.000154282,0.0002138574,0.00008541403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006156838,0.00006491856,0.0005538856,0.0000931324,0.00001682886,0.00005912075,0.00006110498,0.000258494,0.9883177,0.000801241,0.0001198911,0.009592052],"study_design_scores_gemma":[0.000008153285,0.00007679575,0.001850928,0.00001073084,0.00001397457,0.00024521,0.00001545563,0.00951796,0.9853336,0.0006206474,0.002275737,0.00003084999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6068736,0.008251743,0.3777515,0.0003134425,0.0001769973,0.0002697914,0.0008274281,0.002052493,0.003483066],"genre_scores_gemma":[0.7412248,0.003653065,0.2484775,0.0002080125,0.00006486507,0.0004623263,0.0009945312,0.0002078681,0.004707201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001144726,"threshold_uncertainty_score":0.004796982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054809867838185,"score_gpt":0.2148924541128086,"score_spread":0.2043443554344267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}