{"id":"W2084602025","doi":"10.1038/nchembio.1717","title":"Acetylation serves as a protective group in noscapine biosynthesis in opium poppy","year":2014,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Noscapine; Opium Poppy; Biosynthesis; Chemistry; Stereochemistry; Hydroxylation; Moiety; Acetylation; Hemiacetal; Benzylisoquinoline; Biochemistry; Papaver; Enzyme; Biology; Alkaloid; Gene; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128188,0.0004619338,0.0002062598,0.000181736,0.0005975318,0.0003694583,0.0002552424,0.0003172846,0.001551252],"category_scores_gemma":[0.0001653129,0.0002326241,0.0003771369,0.0001587397,0.0004029317,0.0004455738,0.0004222053,0.0004892906,0.0004385114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003205246,"about_ca_system_score_gemma":0.0003960195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001404781,"about_ca_topic_score_gemma":0.001938087,"domain_scores_codex":[0.9998964,0.0000151331,0.000005165235,0.00002945664,0.00001421304,0.00003968042],"domain_scores_gemma":[0.9998006,0.00001975144,0.0000507072,0.00003951417,0.00003087799,0.00005862185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002857956,0.000008885047,0.001057404,0.00002750199,0.000008302921,0.000101245,0.00004777209,0.00003526146,0.9971022,0.0002877242,0.00002027564,0.001017636],"study_design_scores_gemma":[0.00001164041,0.0001935933,0.03925925,0.000007675318,0.00002915324,0.0002121831,0.00008728189,0.0003210733,0.9572101,0.0003890278,0.002265588,0.00001350033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937966,0.0008130875,0.002694469,0.00017281,0.00003176612,0.00001377819,0.0002243957,0.00007458035,0.002178573],"genre_scores_gemma":[0.9963142,0.0002485891,0.0008529101,0.00005026301,0.0000120915,0.000006017058,0.000308255,0.00002858811,0.002178925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001551252,"threshold_uncertainty_score":0.005189419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008652405316494385,"score_gpt":0.3156261327954359,"score_spread":0.3069737274789415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}