{"id":"W2084606843","doi":"10.1042/0264-6021:3560223","title":"Inhibition of Escherichia coli CTP synthase by glutamate γ-semialdehyde and the role of the allosteric effector GTP in glutamine hydrolysis","year":2001,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Purdue University","keywords":"Glutamine; Glutamate synthase; Chemistry; Biochemistry; Allosteric regulation; GTP'; Glutaminase; Active site; ATP synthase; Glutamine amidotransferase; Enzyme; Adenylylation; Stereochemistry; Amidohydrolase; Tryptophan synthase; Glutamine synthetase; Amino acid; Biosynthesis; Tryptophan","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001543796,0.0004023519,0.0003615513,0.00008276459,0.0000640801,0.0002236591,0.0003572709,0.0003621855,0.0003764062],"category_scores_gemma":[0.0002006913,0.0001287511,0.0002004969,0.000165213,0.0002445849,0.0001369256,0.0001924463,0.000363696,0.0001723131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003280056,"about_ca_system_score_gemma":0.0002298382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001554032,"about_ca_topic_score_gemma":0.001205096,"domain_scores_codex":[0.9998313,0.00004625287,0.00002339269,0.00002606142,0.00004872969,0.00002428211],"domain_scores_gemma":[0.9998971,0.00004219022,0.00001958634,0.0000120029,0.00001196029,0.00001719543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001739553,0.0000272922,0.0001265169,0.00003153926,0.000003940962,0.0000505534,0.00001112286,0.0001941263,0.998391,0.00007021951,0.00001529952,0.0009043957],"study_design_scores_gemma":[0.00001235721,0.0001560107,0.001065429,0.000004565635,0.000005520068,0.00009280313,0.000008061834,0.001361462,0.9967535,0.00002332693,0.0005133252,0.000003540932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956214,0.001458818,0.001766847,0.00009466676,0.00001555331,0.00001981048,0.0002135624,0.00003719109,0.0007721364],"genre_scores_gemma":[0.99677,0.0005825805,0.001589278,0.00002787586,0.000003214435,0.00001893312,0.0003367122,0.00001312552,0.0006582396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001554032,"threshold_uncertainty_score":0.003089905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003682313449025903,"score_gpt":0.2201204206989253,"score_spread":0.2164381072498994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}