{"id":"W2084647140","doi":"10.1016/j.jmb.2013.06.015","title":"Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases","year":2013,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Ministero dello Sviluppo Economico; Medical Research Council; Ontario Ministry of Economic Development and Innovation; Diamond Light Source; Canadian Institutes of Health Research; Genome Canada; Australian Research Council; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Ankyrin repeat; Cullin; Ubiquitin ligase; Biology; Ankyrin; Cell biology; Ubiquitin; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004900547,0.0002287391,0.0001184825,0.0001635378,0.0001669445,0.0004119515,0.0002676721,0.0001433529,0.0006786156],"category_scores_gemma":[0.00007282024,0.0001026672,0.000109161,0.0001572733,0.0001419929,0.000230632,0.0001090568,0.0001313077,0.0002761666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006054533,"about_ca_system_score_gemma":0.0002817809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001537913,"about_ca_topic_score_gemma":0.001292229,"domain_scores_codex":[0.9999686,0.000004561304,0.000002402501,0.000009294124,0.000008634513,0.000006523536],"domain_scores_gemma":[0.9999782,0.000001564301,0.000006467944,0.000002153371,0.000003635673,0.000008123039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002702439,0.00004215277,0.003805963,0.0001917201,0.00004284128,0.000507259,0.0001012981,0.01654376,0.9540219,0.01052262,0.0004997458,0.01345044],"study_design_scores_gemma":[0.00006988,0.0005680009,0.065997,0.00006279608,0.0001264843,0.001962735,0.0003220411,0.1506476,0.7253245,0.007461178,0.0473686,0.00008914371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877351,0.002144046,0.006773625,0.00006833538,0.000008099235,0.00001138279,0.0002409148,0.0001106171,0.002907826],"genre_scores_gemma":[0.9947675,0.0006631419,0.003143563,0.00001502828,0.000002852711,0.000005294439,0.0003715693,0.000006677059,0.001024364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001537913,"threshold_uncertainty_score":0.004392862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00784080385157853,"score_gpt":0.2429772010908727,"score_spread":0.2351363972392942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}