{"id":"W2084667421","doi":"10.1016/j.ccr.2014.02.004","title":"Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition","year":2014,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":779,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; University of Toronto; SickKids Foundation; Occupational Cancer Research Centre; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Bundesministerium für Bildung und Forschung; Brain Tumour Charity; Deutsche Krebshilfe; Roche; Novartis","keywords":"Smoothened; PTCH1; Sonic hedgehog; Medulloblastoma; GLI2; Hedgehog signaling pathway; Biology; Germline; Cancer research; Mutation; Germline mutation; Genetics; Patched; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00969108919426951,"score_gpt":0.2308241976960062,"score_spread":0.2211331085017367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}