{"id":"W2084680588","doi":"10.1016/j.bcp.2004.04.030","title":"DNA methylation and breast cancer","year":2004,"lang":"en","type":"review","venue":"Biochemical Pharmacology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; DNA demethylation; Epigenome; Biology; Methylation; Gene silencing; Cancer research; Epigenomics; Chromatin; Cancer; Epigenetics; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001452073,0.0003652555,0.0006247345,0.00008215402,0.0000581552,0.00001734276,0.0001844072,0.0007438862,0.0001098507],"category_scores_gemma":[0.00002002433,0.0003272596,0.000208467,0.0001260298,0.0001467506,0.000002324532,0.0001899589,0.000231363,0.00001455886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007269112,"about_ca_system_score_gemma":0.0002850634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001186536,"about_ca_topic_score_gemma":5.302188e-7,"domain_scores_codex":[0.9984633,0.0001251394,0.0003896319,0.0006261145,0.0001015012,0.0002943176],"domain_scores_gemma":[0.9993244,0.00003007886,0.0002219845,0.0001906918,0.00007076695,0.0001620905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004543128,0.0001163835,0.000005501149,0.005560128,0.0004697058,0.000005550452,0.000009855093,0.000004460303,0.3732306,0.00003255135,0.01148307,0.6090367],"study_design_scores_gemma":[0.0003954406,0.0000541882,0.00001180372,0.0004569978,0.0006445452,0.0000264203,9.714763e-7,0.000001843708,0.05210983,0.0000723591,0.9458328,0.0003927265],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00196945,0.9966702,0.0000794306,0.00007941356,0.0004716569,0.0004289915,0.0001913499,0.00001669351,0.0000928501],"genre_scores_gemma":[0.00134415,0.996519,0.0001483355,0.00008605124,0.001030778,0.000154337,0.0005238359,0.00005783931,0.0001357062],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9343498,"threshold_uncertainty_score":0.9999179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02710037226196546,"score_gpt":0.3731477919329796,"score_spread":0.3460474196710142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}