{"id":"W2084719381","doi":"10.1016/j.bmcl.2008.06.085","title":"Efficient parallel synthesis of macrocyclic peptidomimetics","year":2008,"lang":"fr","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Peptidomimetic; Chemistry; Chemical synthesis; Solid-phase synthesis; Combinatorial chemistry; Stereochemistry; In vitro; Biochemistry; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002942197,0.0005338392,0.0007954468,0.00004516918,0.0001556407,0.00001218263,0.0006012543,0.0005070262,0.001409595],"category_scores_gemma":[0.000637945,0.0005283657,0.0005924626,0.0003464287,0.001306124,0.000003069908,0.0002161373,0.0003300205,0.00007663597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001235065,"about_ca_system_score_gemma":0.0001758588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008933299,"about_ca_topic_score_gemma":0.000001871078,"domain_scores_codex":[0.9969317,0.00009218546,0.0008501877,0.0008005184,0.0005993685,0.0007260608],"domain_scores_gemma":[0.9980923,0.0001508886,0.0004253521,0.0007986106,0.0001247474,0.0004081165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001147427,0.0003775119,0.001055888,0.0004436324,0.000479745,0.00008922493,0.00008205124,0.0001208261,0.9860316,0.000003888528,0.009516531,0.001684349],"study_design_scores_gemma":[0.0006855678,0.00003734033,0.0004984268,0.0002733596,0.0005778167,0.0003411037,0.0001528341,0.000272803,0.9765064,0.000002802762,0.02012579,0.000525718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795786,0.01077373,0.0009028309,0.007192652,0.0002311216,0.0001277259,0.00009624483,0.00001885571,0.001078269],"genre_scores_gemma":[0.9931745,0.002444981,0.001025636,0.0006482215,0.001282502,0.00001623584,0.00007212348,0.00006795691,0.001267849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01359593,"threshold_uncertainty_score":0.9997168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00874054554600597,"score_gpt":0.2095659188674193,"score_spread":0.2008253733214133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}