{"id":"W2084719381","doi":"10.1016/j.bmcl.2008.06.085","title":"Efficient parallel synthesis of macrocyclic peptidomimetics","year":2008,"lang":"fr","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Peptidomimetic; Chemistry; Chemical synthesis; Solid-phase synthesis; Combinatorial chemistry; Stereochemistry; In vitro; Biochemistry; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002323184,0.0005878104,0.0007594845,0.0003110853,0.0003216864,0.0006426635,0.0004665224,0.0002985596,0.003439664],"category_scores_gemma":[0.0002556939,0.0003079309,0.0002575213,0.0004340198,0.0002193841,0.0006683802,0.0007331116,0.0006790516,0.001230318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004907498,"about_ca_system_score_gemma":0.000630977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003107556,"about_ca_topic_score_gemma":0.0008610717,"domain_scores_codex":[0.9997812,0.00002443568,0.00001810441,0.00005106917,0.00007071965,0.000054471],"domain_scores_gemma":[0.9998955,0.00001979118,0.00002076651,0.00002056838,0.00001461407,0.00002874943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008631404,0.0001759003,0.0002333222,0.0003691048,0.00005190972,0.0004265199,0.00009238,0.008501587,0.8923738,0.008802428,0.001486145,0.0866238],"study_design_scores_gemma":[0.0002747929,0.00106935,0.0004494895,0.00001632435,0.0000468477,0.0003961393,0.0000306037,0.01827962,0.9527686,0.003320553,0.02331432,0.00003349521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7989808,0.00510856,0.1481392,0.0004639984,0.0005378514,0.000617201,0.002069531,0.002173225,0.04190962],"genre_scores_gemma":[0.8772597,0.002582721,0.1092646,0.000141405,0.00008612645,0.0003115733,0.001108356,0.0002106022,0.009034837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003439664,"threshold_uncertainty_score":0.0115068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00874054554600597,"score_gpt":0.2095659188674193,"score_spread":0.2008253733214133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}