{"id":"W2084734566","doi":"10.1021/bi992151o","title":"Interaction of a Semirigid Agonist with <i>Torpedo</i> Acetylcholine Receptor","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Torpedo; Methiodide; Chemistry; Acetylcholine receptor; Agonist; Biophysics; Alpha-4 beta-2 nicotinic receptor; Nicotinic acetylcholine receptor; Receptor; Acetylcholine; Nicotinic agonist; Stereochemistry; Biochemistry; Biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001313974,0.0003519432,0.0004575902,0.00009035998,0.0001534516,0.000326984,0.0003003451,0.0003030586,0.0009782806],"category_scores_gemma":[0.000251453,0.0001373936,0.0003319947,0.0001563144,0.0002633189,0.0001534854,0.0002680577,0.0003134458,0.0002421532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004326047,"about_ca_system_score_gemma":0.0001784946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009245133,"about_ca_topic_score_gemma":0.001198722,"domain_scores_codex":[0.9998434,0.00002828175,0.00001080603,0.00003085406,0.00003762493,0.00004891363],"domain_scores_gemma":[0.9999063,0.00002768704,0.00002420553,0.00001313296,0.000007835837,0.00002079428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00028261,0.0000100728,0.0001574886,0.00004158611,0.00001256311,0.00007390752,0.00001368431,0.00007992856,0.9987862,0.00004356691,0.00002456797,0.0004737623],"study_design_scores_gemma":[0.00004523843,0.0007611425,0.009041727,0.000009550029,0.00005513186,0.0005725369,0.00008137708,0.00148528,0.9861648,0.00003263879,0.001725876,0.0000245632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982823,0.0004933534,0.0004562614,0.00002570455,0.000009055791,0.00001158659,0.0001030763,0.00001623851,0.0006025607],"genre_scores_gemma":[0.99771,0.0006182282,0.0006792823,0.00005132538,0.00000569084,0.00002177812,0.0002944083,0.000009595461,0.0006096645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009782806,"threshold_uncertainty_score":0.003272712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007068455683638911,"score_gpt":0.2327166504166838,"score_spread":0.2256481947330449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}