{"id":"W2084785039","doi":"10.1158/2326-6066.cir-14-0177","title":"Cell-free Tumor Microparticle Vaccines Stimulate Dendritic Cells via cGAS/STING Signaling","year":2014,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Huazhong University of Science and Technology","keywords":"Antigen; Immunotherapy; Dendritic cell; Immune system; Cancer research; Immunology; DNA vaccination; T cell; Innate immune system; Antigen presentation; Biology; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001738616,0.0003421528,0.0005553908,0.0004539267,0.0008634346,0.00007218183,0.001291335,0.000340635,0.002805504],"category_scores_gemma":[0.00061021,0.000318551,0.0001566477,0.0004653474,0.0008184031,0.0001596033,0.000779238,0.001474174,0.003012335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00019525,"about_ca_system_score_gemma":0.0002257653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006864504,"about_ca_topic_score_gemma":0.00003948659,"domain_scores_codex":[0.9948702,0.002017977,0.0006073031,0.0006878698,0.0001192804,0.001697329],"domain_scores_gemma":[0.9967679,0.001442055,0.0001389343,0.001052969,0.0005371364,0.00006101738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001036021,0.00015407,0.0009255812,0.00005882523,0.0001842563,0.00002058499,0.0004396361,0.00006840022,0.9870039,0.0001469496,0.006065523,0.003896306],"study_design_scores_gemma":[0.002899008,0.0006709922,0.001368941,0.0001151057,0.00003766342,0.0001104387,0.0004569261,0.0001731817,0.9697191,0.0003183887,0.02379005,0.0003402533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721905,0.02330242,0.0003761249,0.000691812,0.001683033,0.00039127,0.00001963417,0.0001549422,0.001190264],"genre_scores_gemma":[0.990828,0.0002382519,0.0001293643,0.000261864,0.0001276103,0.0001431051,0.00001552472,0.00006965552,0.008186606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02306417,"threshold_uncertainty_score":0.9999266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0358350077736466,"score_gpt":0.328043116793005,"score_spread":0.2922081090193584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}