{"id":"W2084822078","doi":"10.1038/sj.cdd.4400769","title":"Quantitative analysis of fluorescent caspase substrate cleavage in intact cells and identification of novel inhibitors of apoptosis","year":2001,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Cleavage (geology); Caspase; Förster resonance energy transfer; Cell biology; Apoptosis; Caspase 3; Chemistry; Programmed cell death; Caspase 8; Green fluorescent protein; Cell culture; Cell; Biochemistry; Biology; Fluorescence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001249153,0.00008788819,0.0001920436,0.0002170575,0.00001825757,0.0000070473,0.00003282805,0.00009057019,0.000003299195],"category_scores_gemma":[0.00001085819,0.0000822894,0.00006119082,0.0002162153,0.0000343375,0.000008174982,0.00002359697,0.00002656082,6.931474e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006030419,"about_ca_system_score_gemma":0.00001028209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001227479,"about_ca_topic_score_gemma":0.00008072103,"domain_scores_codex":[0.9992385,0.00003090699,0.0003748099,0.0001878395,0.00009014073,0.00007778747],"domain_scores_gemma":[0.9994637,0.00001374939,0.000298176,0.0001194841,0.00007225454,0.000032648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001056414,0.0001871015,0.04256516,0.00007227789,0.00006177212,1.036355e-7,0.0001776947,0.0003275681,0.9556282,0.000244765,0.000001644817,0.0006280625],"study_design_scores_gemma":[0.0004017911,0.0001033165,0.2852778,0.00001113694,0.0001606533,1.581249e-7,0.0001315686,0.009177306,0.7046549,0.00002581643,0.000001619929,0.000053868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895053,0.0002933873,0.00995965,0.000003959495,0.00004190758,0.0001310393,0.00003366157,0.000001475536,0.00002963242],"genre_scores_gemma":[0.9983128,0.001114379,0.0002801196,0.000002120014,0.000007613882,0.000003162185,0.0002487451,0.00000559259,0.00002551104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2509733,"threshold_uncertainty_score":0.3355664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369696811966827,"score_gpt":0.2431029275772204,"score_spread":0.2294059594575521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}