{"id":"W2084822078","doi":"10.1038/sj.cdd.4400769","title":"Quantitative analysis of fluorescent caspase substrate cleavage in intact cells and identification of novel inhibitors of apoptosis","year":2001,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Cleavage (geology); Caspase; Förster resonance energy transfer; Cell biology; Apoptosis; Caspase 3; Chemistry; Programmed cell death; Caspase 8; Green fluorescent protein; Cell culture; Cell; Biochemistry; Biology; Fluorescence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001189145,0.0009631651,0.0009387156,0.001002353,0.0004928053,0.0007632868,0.0009307443,0.0006231495,0.00144568],"category_scores_gemma":[0.000738551,0.0004514022,0.0005904889,0.00109702,0.0006514163,0.0008558249,0.0002676576,0.001849368,0.0004090864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001355689,"about_ca_system_score_gemma":0.0005693631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006407141,"about_ca_topic_score_gemma":0.001183515,"domain_scores_codex":[0.999229,0.0001372731,0.00007822963,0.0001362457,0.0002469813,0.0001723694],"domain_scores_gemma":[0.9991286,0.0003226614,0.0001480319,0.0001370281,0.0001781379,0.00008551053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002275252,0.00007967046,0.0000808552,0.00004861586,0.000008864583,0.00001766393,0.00001836474,0.0001261222,0.9973304,0.0003520679,0.00004833461,0.001661421],"study_design_scores_gemma":[0.00001834006,0.00009215961,0.0005532037,0.000001859578,0.00001041212,0.00005514807,0.000005847469,0.001001421,0.9976851,0.00005661643,0.0005172294,0.000002758379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7883842,0.007642515,0.1965641,0.0003141949,0.0001442709,0.000514906,0.001638935,0.0007921365,0.004004726],"genre_scores_gemma":[0.8456956,0.005123594,0.1376175,0.0001375928,0.00006997895,0.001138241,0.004081011,0.0002085174,0.005928149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00144568,"threshold_uncertainty_score":0.009836257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369696811966827,"score_gpt":0.2431029275772204,"score_spread":0.2294059594575521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}