{"id":"W2084886244","doi":"10.1002/1099-0690(200006)2000:11<2095::aid-ejoc2095>3.0.co;2-j","title":"Synthesis of Geometrically Constrained Unsymmetrical Bis(polyamides) Related to the Antiviral Distamycin","year":2000,"lang":"en","type":"article","venue":"European Journal of Organic Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Netropsin; Chemistry; Linker; Oligopeptide; Polyamide; Stereochemistry; Minor groove; Sequence (biology); DNA; Base pair; Amidine; Base (topology); Combinatorial chemistry; Peptide; Biochemistry; Polymer chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547297,0.0003620428,0.0001745553,0.0001108454,0.0001220487,0.0002675394,0.0003085727,0.0001860852,0.001338988],"category_scores_gemma":[0.0002995329,0.0001807533,0.0001862956,0.0001509918,0.0002203383,0.0003219895,0.0002069692,0.0005593062,0.000447979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002211824,"about_ca_system_score_gemma":0.0003050053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001425884,"about_ca_topic_score_gemma":0.0004090428,"domain_scores_codex":[0.9999074,0.00001605055,0.00001164179,0.0000266475,0.00002136202,0.00001688367],"domain_scores_gemma":[0.9997546,0.00003225467,0.0001194332,0.00002501222,0.00002239094,0.00004627328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009836581,0.00003955108,0.00008856881,0.0001035243,0.000006485775,0.00008771652,0.00004167232,0.001195041,0.9898032,0.001311871,0.00004758538,0.007176345],"study_design_scores_gemma":[0.0000421461,0.0006715206,0.0005114248,0.000007450403,0.00002227073,0.0001853565,0.00001975758,0.00101983,0.9907553,0.0002529401,0.006497215,0.00001469884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9507565,0.001161022,0.04148586,0.00007931104,0.00007465939,0.000197578,0.000344207,0.0001692713,0.005731512],"genre_scores_gemma":[0.9311191,0.001170549,0.06440743,0.00006563472,0.00002616302,0.0001346824,0.0004550016,0.00006078706,0.002560674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001338988,"threshold_uncertainty_score":0.004479349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00403652172999706,"score_gpt":0.1982517989926948,"score_spread":0.1942152772626977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}