{"id":"W2084887094","doi":"10.1023/b:pham.0000048200.98837.6f","title":"A Novel Oral Vehicle for Poorly Soluble HSV-Helicase Inhibitors: PK/PD Validations","year":2004,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Pharmacology; Helicase; HSL and HSV; Chemistry; Medicine; Virology; Biochemistry; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006447291,0.0004850967,0.0005905877,0.0003237842,0.0002991408,0.0007848208,0.0004200826,0.0004178462,0.003396532],"category_scores_gemma":[0.000469858,0.0002390649,0.0003463722,0.0001578463,0.0003811727,0.0008586863,0.0002838157,0.001051923,0.0007606649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004393572,"about_ca_system_score_gemma":0.0007230851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009559277,"about_ca_topic_score_gemma":0.001242092,"domain_scores_codex":[0.9998019,0.00004568821,0.00001488962,0.00003897342,0.0000549595,0.00004354676],"domain_scores_gemma":[0.9998379,0.0000524967,0.00003263722,0.00002285008,0.00003035238,0.00002373754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002417687,0.0006273225,0.0003006503,0.0006967641,0.00006422887,0.0002954286,0.0001614005,0.001454028,0.9166365,0.001729038,0.001060867,0.07455608],"study_design_scores_gemma":[0.0004356847,0.005770903,0.0005490658,0.00003397758,0.00009728089,0.0006346782,0.0000658098,0.002092892,0.9730356,0.0002560169,0.01700871,0.00001939262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9293728,0.02006397,0.03503122,0.0007975938,0.0003272573,0.001246853,0.001331115,0.0003822799,0.0114469],"genre_scores_gemma":[0.9662602,0.007794294,0.01541153,0.0001265945,0.00007037378,0.000300532,0.0007969867,0.00006879008,0.009170627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003396532,"threshold_uncertainty_score":0.01136255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3662727320261369,"score_gpt":0.5454829703310334,"score_spread":0.1792102383048966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}