{"id":"W2084891840","doi":"10.1002/ijc.27361","title":"Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer <i>in vivo</i>","year":2011,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Alnylam Pharmaceuticals","keywords":"Gene silencing; In vivo; Prostate cancer; Androgen receptor; Cancer research; Cancer; Receptor; Prostate; Medicine; Biology; Internal medicine; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001620256,0.0003567924,0.0002134573,0.0001375018,0.0001334325,0.0002942712,0.0001939898,0.0003186311,0.0007714759],"category_scores_gemma":[0.00009542666,0.0001369858,0.0002202262,0.0001053547,0.0001197622,0.0002151145,0.0001526271,0.0003568451,0.0004287349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000423056,"about_ca_system_score_gemma":0.0002310683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001149077,"about_ca_topic_score_gemma":0.001474804,"domain_scores_codex":[0.9998909,0.00001963437,0.000009066846,0.00002883285,0.00003529304,0.00001630009],"domain_scores_gemma":[0.9999703,0.000004831794,0.000009522232,0.000002434505,0.000008292347,0.000004484363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003454288,0.0000146398,0.00002639646,0.00004451989,0.000004440796,0.0000152556,0.000009008342,0.0000807469,0.9982904,0.00007338676,0.00005847728,0.001348236],"study_design_scores_gemma":[0.00000908634,0.0001902215,0.0002265348,0.000002440018,0.00001160267,0.00005124691,0.000004468021,0.0004093859,0.9968831,0.00001009426,0.002199071,0.000002717611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9407021,0.01027804,0.03894498,0.0004480557,0.0001416374,0.0003732114,0.0009407087,0.0005484626,0.007622797],"genre_scores_gemma":[0.9669511,0.004226262,0.0202701,0.0002085218,0.00002286059,0.0002470364,0.0008333118,0.00006802986,0.007172894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001149077,"threshold_uncertainty_score":0.00306952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995682149423682,"score_gpt":0.29554663653724,"score_spread":0.2755898150430032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}