{"id":"W2084899195","doi":"10.1038/ncomms3490","title":"Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction","year":2013,"lang":"en","type":"article","venue":"Nature Communications","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":217,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Office of Science; National Institutes of Health; McGill University; W. M. Keck Foundation","keywords":"Polymorphism (computer science); Growth cone; Cone (formal languages); Biology; Cell biology; Genetics; Computer science; Gene; Genotype; Axon","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002169162,0.0004724902,0.0002951557,0.0002861428,0.0002532438,0.0002381554,0.0002659403,0.0005954141,0.003138001],"category_scores_gemma":[0.0003350044,0.0002580099,0.0006095283,0.000157034,0.000397307,0.0001153152,0.0002624244,0.0008516605,0.0005253226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002734452,"about_ca_system_score_gemma":0.0003289193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001897728,"about_ca_topic_score_gemma":0.002513301,"domain_scores_codex":[0.9996722,0.0000710586,0.00006626605,0.00006067575,0.00006501982,0.00006476256],"domain_scores_gemma":[0.9996593,0.00006577938,0.0001320409,0.00003190943,0.00002275749,0.00008822978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001853125,0.0002235456,0.001167797,0.00003928059,0.00007141806,0.0005890481,0.0000391699,0.0001965504,0.9927121,0.0002046457,0.0001451736,0.002758228],"study_design_scores_gemma":[0.001638038,0.00756822,0.06598037,0.00007118725,0.0004198264,0.008028039,0.000226558,0.004618901,0.9048257,0.0009422369,0.005581395,0.00009948573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982806,0.0001262102,0.0007452013,0.0001000237,0.00007868421,0.00001738624,0.0001789689,0.00002870461,0.0004442274],"genre_scores_gemma":[0.9983759,0.00007509547,0.0004727151,0.00006505085,0.00001355842,0.00001108599,0.0001114551,0.00002464417,0.0008505184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003138001,"threshold_uncertainty_score":0.01049769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02994242094017298,"score_gpt":0.2965241934774823,"score_spread":0.2665817725373094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}