{"id":"W2084899195","doi":"10.1038/ncomms3490","title":"Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction","year":2013,"lang":"en","type":"article","venue":"Nature Communications","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":217,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Office of Science; National Institutes of Health; McGill University; W. M. Keck Foundation","keywords":"Polymorphism (computer science); Growth cone; Cone (formal languages); Biology; Cell biology; Genetics; Computer science; Gene; Genotype; Axon","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001306518,0.0001339368,0.0001446804,0.0001672156,0.0003108234,0.00004894105,0.0009208352,0.0002748253,0.00009743176],"category_scores_gemma":[0.0006814952,0.0001185071,0.00005626149,0.0005368256,0.0001658502,0.0003731084,0.0002053578,0.001027827,0.00004664354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004035349,"about_ca_system_score_gemma":0.00005187383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005765651,"about_ca_topic_score_gemma":0.00005581912,"domain_scores_codex":[0.9986271,0.0003639108,0.0002830169,0.0002733947,0.0002832993,0.0001693053],"domain_scores_gemma":[0.9980426,0.0003030642,0.0001800667,0.001190997,0.00018887,0.00009438934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001051594,0.0000755913,0.0001983898,0.000005748961,0.000004344899,2.061347e-7,0.0001205453,0.00001391505,0.964119,0.02941324,0.00523588,0.0008026533],"study_design_scores_gemma":[0.0001803276,0.0000858978,0.01822216,0.00001516853,0.00001449199,0.0000189186,0.00002385049,0.0001849081,0.9740009,0.002062056,0.005039551,0.0001517115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740166,0.0001962237,0.0001530777,0.02264647,0.0006173074,0.0006957579,0.00008895528,0.00007282824,0.001512763],"genre_scores_gemma":[0.9927983,0.00004940551,0.00426918,0.002421675,0.00009710518,0.00004787069,0.00004493645,0.00001809918,0.0002534622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02735119,"threshold_uncertainty_score":0.4832578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02994242094017298,"score_gpt":0.2965241934774823,"score_spread":0.2665817725373094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}