{"id":"W2084905199","doi":"10.1016/j.jmb.2007.06.050","title":"Crystal Structure of Conserved Domains 1 and 2 of the Human DEAD-box Helicase DDX3X in Complex with the Mononucleotide AMP","year":2007,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; Karolinska Institutet; VINNOVA; Stiftelsen för Strategisk Forskning; Canadian Institutes of Health Research; Genome Canada; Ontario Innovation Trust; Wellcome Trust; Carl Tryggers Stiftelse för Vetenskaplig Forskning; GlaxoSmithKline","keywords":"Helicase; RNA Helicase A; DEAD box; Binding site; Biology; RNA; Cytoplasm; Biochemistry; ATP hydrolysis; Binding domain; Messenger RNA; Biophysics; Chemistry; Crystallography; Cell biology; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004672866,0.0001054448,0.0002262614,0.00006977475,0.00005204377,0.00000602757,0.000286255,0.0001056663,0.000007280199],"category_scores_gemma":[0.0000796208,0.00005528031,0.00009058006,0.0001109333,0.0004569237,0.000002407827,0.0001171299,0.0002089352,4.994213e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001230552,"about_ca_system_score_gemma":0.00007194096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001081803,"about_ca_topic_score_gemma":0.001118873,"domain_scores_codex":[0.9989994,0.0002014986,0.0003471914,0.0001183252,0.0001254656,0.0002081894],"domain_scores_gemma":[0.9991737,0.00004020176,0.0003301112,0.0002392437,0.000153321,0.00006342521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002666475,0.00003037233,0.02325535,0.00001294139,0.0000814416,0.00002197649,0.00003363515,0.00003290603,0.975702,0.0002964211,0.00007257025,0.0001936972],"study_design_scores_gemma":[0.001352544,0.0008138253,0.069323,0.00002854108,0.00002214964,0.0003610737,0.0002317655,0.000006002453,0.9267963,0.0002210943,0.0007607592,0.0000829678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969778,0.0004777936,0.001937728,0.000393446,0.00001461988,0.000127123,0.00001745987,5.806725e-7,0.00005345494],"genre_scores_gemma":[0.9987581,0.00002953429,0.0009364057,0.0002094574,0.00003326783,4.174274e-7,0.000006870017,0.000009617233,0.00001632291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04890577,"threshold_uncertainty_score":0.2254266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264909170192898,"score_gpt":0.2948526318908126,"score_spread":0.2822035401888836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}