{"id":"W2084905199","doi":"10.1016/j.jmb.2007.06.050","title":"Crystal Structure of Conserved Domains 1 and 2 of the Human DEAD-box Helicase DDX3X in Complex with the Mononucleotide AMP","year":2007,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; Karolinska Institutet; VINNOVA; Stiftelsen för Strategisk Forskning; Canadian Institutes of Health Research; Genome Canada; Ontario Innovation Trust; Wellcome Trust; Carl Tryggers Stiftelse för Vetenskaplig Forskning; GlaxoSmithKline","keywords":"Helicase; RNA Helicase A; DEAD box; Binding site; Biology; RNA; Cytoplasm; Biochemistry; ATP hydrolysis; Binding domain; Messenger RNA; Biophysics; Chemistry; Crystallography; Cell biology; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002349048,0.0004119233,0.0007365791,0.0002039482,0.0005704905,0.0007326339,0.000675781,0.0006517926,0.002294612],"category_scores_gemma":[0.0003480255,0.0003242908,0.000202761,0.0003094206,0.0003217658,0.0003543071,0.0002479434,0.001260974,0.0003120994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009503048,"about_ca_system_score_gemma":0.0005361396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002807226,"about_ca_topic_score_gemma":0.00401473,"domain_scores_codex":[0.9998742,0.00001339444,0.000008127077,0.00002832744,0.00004737289,0.0000285877],"domain_scores_gemma":[0.9998385,0.00004907838,0.00003807269,0.000007418813,0.0000192631,0.00004773181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005351172,0.000999955,0.01864759,0.001115101,0.0005175734,0.006856979,0.001092266,0.007965439,0.9161096,0.005129174,0.01752291,0.01869239],"study_design_scores_gemma":[0.002176851,0.001233816,0.1651033,0.0002388732,0.0004587343,0.0100492,0.002015552,0.08572068,0.6747504,0.002353106,0.05559815,0.0003013062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911452,0.004034997,0.0008984903,0.000528366,0.0001166883,0.00002335194,0.001009192,0.0001204629,0.00212324],"genre_scores_gemma":[0.9900504,0.001705388,0.001554211,0.0002607838,0.00003326817,0.00002637666,0.003174621,0.00002614246,0.003168806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002807226,"threshold_uncertainty_score":0.007676184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264909170192898,"score_gpt":0.2948526318908126,"score_spread":0.2822035401888836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}