{"id":"W2084941037","doi":"10.1007/s10549-010-1022-9","title":"Results of a phase II study comparing three dosing regimens of fulvestrant in postmenopausal women with advanced breast cancer (FINDER2)","year":2010,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"Regional Municipality of Durham; Jewish General Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"AstraZeneca","keywords":"Fulvestrant; Tolerability; Medicine; Discontinuation; Dosing; Breast cancer; Internal medicine; Clinical endpoint; Hazard ratio; Cancer; Pharmacokinetics; Aromatase inhibitor; Oncology; Gastroenterology; Urology; Confidence interval; Adverse effect; Randomized controlled trial; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002957294,0.002490938,0.00397871,0.0007352228,0.0006954995,0.001060061,0.001345919,0.002314942,0.004410718],"category_scores_gemma":[0.002544234,0.0009343103,0.002586291,0.0006635851,0.001705015,0.001307882,0.0003628626,0.003985167,0.0009357535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008505398,"about_ca_system_score_gemma":0.00177745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001870733,"about_ca_topic_score_gemma":0.002530063,"domain_scores_codex":[0.998968,0.0005727641,0.00005333781,0.0001473223,0.00008204897,0.0001765158],"domain_scores_gemma":[0.9980367,0.0006779028,0.0003164218,0.0002797819,0.0001021612,0.0005870051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9040966,0.04429935,0.001356372,0.0002862044,0.001386669,0.00007683423,0.0001624445,0.001083008,0.0183966,0.00007786109,0.0008181236,0.02795997],"study_design_scores_gemma":[0.5707783,0.4209659,0.003677497,0.00001522266,0.0007566448,0.00008757128,0.00004862098,0.0003030686,0.002549555,0.0001193752,0.0006714612,0.00002693793],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916161,0.001858232,0.0009690747,0.0005239116,0.0002168707,0.001998331,0.001683378,0.0001243376,0.001009582],"genre_scores_gemma":[0.982797,0.002557833,0.002796667,0.0012816,0.0004453612,0.002807229,0.003197514,0.0001000588,0.004016767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004410718,"threshold_uncertainty_score":0.0156399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02062371587390918,"score_gpt":0.3414630079312039,"score_spread":0.3208392920572947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}