{"id":"W2084955511","doi":"10.1097/ppo.0000000000000106","title":"Drivers of the Warburg Phenotype","year":2015,"lang":"en","type":"review","venue":"The Cancer Journal","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Warburg effect; Phenotype; Oxidative phosphorylation; Citric acid cycle; Glycolysis; Cell biology; Mitochondrion; Biology; Tumor microenvironment; Metabolic pathway; Metabolism; Chemistry; Biochemistry; Cancer research; Tumor cells; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003110004,0.0005477932,0.0007228036,0.001010734,0.0002573443,0.0009224024,0.0006017963,0.0008721261,0.003216547],"category_scores_gemma":[0.0004145528,0.0002121057,0.0003515376,0.0005835359,0.0004670092,0.0008171569,0.0005893082,0.001623124,0.001436613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007488374,"about_ca_system_score_gemma":0.0006474926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006504569,"about_ca_topic_score_gemma":0.0008985719,"domain_scores_codex":[0.999893,0.00001488956,0.000008871692,0.00002451422,0.00003781638,0.00002097807],"domain_scores_gemma":[0.9998717,0.00004521592,0.00002427705,0.00000569145,0.00002919919,0.00002384344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001235323,0.00005792871,0.0008422065,0.006161991,0.00008283609,0.0009399418,0.00009720635,0.0006262829,0.0125258,0.03192011,0.04284522,0.9037769],"study_design_scores_gemma":[0.00001153046,0.00004730533,0.0008970313,0.0006693694,0.00004875226,0.002549668,0.00003891947,0.00009882643,0.003356599,0.005118482,0.9871474,0.00001601539],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009689977,0.9912436,0.00087388,0.001199656,0.0005068498,0.00001182619,0.00008197884,0.00004579886,0.005067413],"genre_scores_gemma":[0.007800744,0.9885834,0.0003869262,0.0005040378,0.0002249444,0.00001710222,0.0001288689,0.0000061799,0.002347763],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003216547,"threshold_uncertainty_score":0.01076037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0413424184917388,"score_gpt":0.3342026159415596,"score_spread":0.2928601974498208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}