{"id":"W2084955511","doi":"10.1097/ppo.0000000000000106","title":"Drivers of the Warburg Phenotype","year":2015,"lang":"en","type":"review","venue":"The Cancer Journal","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Warburg effect; Phenotype; Oxidative phosphorylation; Citric acid cycle; Glycolysis; Cell biology; Mitochondrion; Biology; Tumor microenvironment; Metabolic pathway; Metabolism; Chemistry; Biochemistry; Cancer research; Tumor cells; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004870039,0.0002244287,0.000585605,0.00002796824,0.0001252002,0.0000226686,0.0009527444,0.0001880978,0.00007576297],"category_scores_gemma":[0.00004686491,0.0001071162,0.0005699754,0.0001352791,0.0001684983,0.000002183468,0.0001975108,0.0004626841,0.000004965765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006478873,"about_ca_system_score_gemma":0.001569103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000227437,"about_ca_topic_score_gemma":0.00002253477,"domain_scores_codex":[0.9987954,0.0002054466,0.0003414786,0.0001805911,0.0002541284,0.0002229849],"domain_scores_gemma":[0.9986012,0.00001019092,0.0005572318,0.000556835,0.000181325,0.00009321104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001394703,0.000009793793,0.00000291477,0.0003496311,0.0002978063,3.576632e-7,0.00006159681,0.00001865742,0.0001858048,0.00002008084,0.07854948,0.9204899],"study_design_scores_gemma":[0.0002019784,0.00002456973,0.000005681896,0.0007437416,0.0007331303,0.00008522041,0.00002166564,3.321282e-7,0.00009683495,0.00009077154,0.9978588,0.0001372761],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000873859,0.9941949,0.00002324177,0.00008350613,0.004619778,0.0002150815,0.00006280964,0.000002157949,0.0007111101],"genre_scores_gemma":[0.0000327825,0.990685,0.00001843092,0.0001306699,0.007006353,0.00001738145,0.000008938648,0.00003464697,0.002065741],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9203526,"threshold_uncertainty_score":0.436807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0413424184917388,"score_gpt":0.3342026159415596,"score_spread":0.2928601974498208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}