{"id":"W2084970853","doi":"10.1111/j.1471-4159.2009.06165.x","title":"The Parkinson disease‐associated A30P mutation stabilizes α‐synuclein against proteasomal degradation triggered by heme oxygenase‐1 over‐expression in human neuroblastoma cells","year":2009,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"University of Toronto","keywords":"Heme oxygenase; Biliverdin; Alpha-synuclein; Heme; Biliverdin reductase; Intracellular; Chemistry; Lactacystin; Proteasome; MG132; Protein degradation; Cell biology; Transfection; Proteasome inhibitor; Molecular biology; Biology; Biochemistry; Internal medicine; Parkinson's disease; Medicine; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638937,0.0002429918,0.0002734194,0.0001547708,0.0002397954,0.0001917802,0.0002086486,0.0002806321,0.0006188001],"category_scores_gemma":[0.00008277509,0.0001388069,0.0002549794,0.0001613811,0.000143792,0.00009890079,0.0001197554,0.0003261558,0.0004067371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000311808,"about_ca_system_score_gemma":0.0002914217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002140491,"about_ca_topic_score_gemma":0.002974472,"domain_scores_codex":[0.9998782,0.00001481191,0.00002169208,0.00002602141,0.00004068382,0.00001870309],"domain_scores_gemma":[0.9999378,0.000009145352,0.00001669329,0.000008934737,0.00000707973,0.00002038837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006543079,0.0000292932,0.0001476612,0.00001822633,0.00000533651,0.0001912032,0.00001725063,0.00004181704,0.998785,0.0000423966,0.00005892381,0.0005974397],"study_design_scores_gemma":[0.00004490706,0.000694689,0.008553765,0.00001370912,0.00003632324,0.001196322,0.00007083932,0.001445745,0.9826798,0.00006326337,0.005191556,0.000009123153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968341,0.001086504,0.000562893,0.00007987999,0.00004221069,0.00003256108,0.0004807192,0.0000447735,0.0008365018],"genre_scores_gemma":[0.9952857,0.0008918062,0.0009906406,0.00003200608,0.000006834866,0.00003278675,0.0007115753,0.000009149211,0.002039386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002140491,"threshold_uncertainty_score":0.00425601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008998038586743008,"score_gpt":0.2498960689404559,"score_spread":0.2408980303537129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}