{"id":"W2084974279","doi":"10.1016/j.ejphar.2004.09.017","title":"Prophylactic and therapeutic effects of acute systemic injections of EMD 281014, a selective serotonin 2A receptor antagonist on anxiety induced by predator stress in rats","year":2004,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Merck KGaA","keywords":"Startle response; Elevated plus maze; Antagonist; Serotonin; Receptor antagonist; Moro reflex; Internal medicine; Pharmacology; Psychology; Anesthesia; Medicine; Endocrinology; Reflex; Anxiety; Receptor; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002449331,0.001136063,0.001077486,0.0006954849,0.0003625303,0.000283255,0.0006375344,0.0008768552,0.003391437],"category_scores_gemma":[0.0004343234,0.0004630395,0.0004681879,0.0002860724,0.001101856,0.0005216226,0.0002726125,0.001795211,0.0004336548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003925656,"about_ca_system_score_gemma":0.000958369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001226085,"about_ca_topic_score_gemma":0.002442814,"domain_scores_codex":[0.9997801,0.00002972728,0.000012867,0.00003914366,0.00003315698,0.0001050765],"domain_scores_gemma":[0.9995977,0.00006181425,0.00007387051,0.00004507636,0.00002261732,0.0001988902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0430032,0.005052497,0.0005428639,0.0002941819,0.00009054559,0.0004250713,0.0001302533,0.0005928522,0.9320626,0.0008289085,0.0006476823,0.01632939],"study_design_scores_gemma":[0.006707651,0.08358746,0.01353634,0.00007596036,0.0003117661,0.0006703283,0.0002128527,0.00267221,0.8887564,0.0006197762,0.00276223,0.00008693911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953908,0.001214938,0.000667087,0.000345306,0.0001344953,0.0001097844,0.000476472,0.0001640758,0.001497156],"genre_scores_gemma":[0.9944936,0.001401596,0.001080559,0.0001141095,0.00009416384,0.0001082831,0.0004032883,0.00001813599,0.002286425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003391437,"threshold_uncertainty_score":0.01134551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01510192789772846,"score_gpt":0.2915477612212057,"score_spread":0.2764458333234772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}