{"id":"W2084979694","doi":"10.1021/bi002035h","title":"FRET Analysis Indicates That the Two ATPase Active Sites of the P-Glycoprotein Multidrug Transporter Are Closely Associated","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"P-glycoprotein; Transporter; ATPase; Glycoprotein; Chemistry; ATP-binding cassette transporter; Förster resonance energy transfer; Multiple drug resistance; Cell biology; Biochemistry; Biology; Gene; Fluorescence; Enzyme; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001826847,0.0003678326,0.0004034727,0.0002267193,0.0002434971,0.0002125342,0.0003938946,0.0006802074,0.000899428],"category_scores_gemma":[0.000476208,0.0001458985,0.0002510553,0.0002124542,0.0003104465,0.0005160219,0.0002511003,0.0005615221,0.0004331011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002367628,"about_ca_system_score_gemma":0.0001085888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002002764,"about_ca_topic_score_gemma":0.0002005384,"domain_scores_codex":[0.9998153,0.00003388495,0.00000873557,0.00006770818,0.00005005637,0.00002436879],"domain_scores_gemma":[0.9998449,0.00005709235,0.00003457375,0.0000169978,0.00002429435,0.00002211517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006434097,0.00002263121,0.001141788,0.00003012697,0.000009055424,0.0001240381,0.0000416127,0.0001658462,0.9947418,0.0007125618,0.00004680673,0.002899381],"study_design_scores_gemma":[0.00001120807,0.0001975898,0.008730957,0.000007311919,0.00001935018,0.001152247,0.00008569482,0.008289601,0.9783989,0.0007455918,0.002347692,0.00001387405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969555,0.0007729172,0.02685841,0.0001375165,0.00001622435,0.00002077638,0.00014872,0.0001179035,0.00237257],"genre_scores_gemma":[0.989863,0.0002483825,0.008883428,0.00003576775,0.00000431365,0.00002001851,0.0002019998,0.000009033348,0.0007339359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000899428,"threshold_uncertainty_score":0.003008902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01445498865324625,"score_gpt":0.2445659256836752,"score_spread":0.230110937030429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}