{"id":"W2084981691","doi":"10.3389/fgene.2013.00211","title":"Immunosenescence is associated with altered gene expression and epigenetic regulation in primary and secondary immune organs","year":2013,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Immunosenescence; Biology; Thymic involution; Epigenetics; Immune system; Immunology; Senescence; DNA methylation; Spleen; Gene expression; Involution (esoterism); Gene; T cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127654,0.0002408019,0.0002457931,0.0005564399,0.0001224586,0.0002038668,0.00009676496,0.0001620208,0.001030903],"category_scores_gemma":[0.0001207441,0.00009505266,0.0001995776,0.0002082116,0.0002480881,0.0001540677,0.0001665311,0.0002359106,0.0001536088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001317929,"about_ca_system_score_gemma":0.0001339811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002275407,"about_ca_topic_score_gemma":0.0002734371,"domain_scores_codex":[0.9999149,0.000009867523,0.00000628171,0.00003473945,0.00001378009,0.00002033032],"domain_scores_gemma":[0.9997844,0.00001582528,0.0001183456,0.00001434842,0.00002734217,0.00003984452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002190705,0.00002421929,0.01281246,0.00003506371,0.00001476165,0.0001987421,0.00007192143,0.00001724874,0.9829727,0.00007355394,0.00002368665,0.003536551],"study_design_scores_gemma":[0.00001132563,0.0008472673,0.7194349,0.00001356083,0.00006676439,0.002052997,0.0001832889,0.000217653,0.2747585,0.0003028856,0.002096601,0.00001437265],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965358,0.001791172,0.00106928,0.00002584687,0.000008243385,0.000007552489,0.0001574258,0.0000252111,0.0003795143],"genre_scores_gemma":[0.9970436,0.001064764,0.0006714455,0.00002408642,0.00001515922,0.00001185715,0.0001807218,0.000006280539,0.0009820276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001030903,"threshold_uncertainty_score":0.003448665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006073960030228963,"score_gpt":0.1966472596034415,"score_spread":0.1905732995732125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}