{"id":"W2084981691","doi":"10.3389/fgene.2013.00211","title":"Immunosenescence is associated with altered gene expression and epigenetic regulation in primary and secondary immune organs","year":2013,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Immunosenescence; Biology; Thymic involution; Epigenetics; Immune system; Immunology; Senescence; DNA methylation; Spleen; Gene expression; Involution (esoterism); Gene; T cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001596514,0.0002320656,0.0004547095,0.0002468341,0.00006631929,0.00003567636,0.00009519725,0.0001846661,0.00006009453],"category_scores_gemma":[0.00004298735,0.0002094763,0.00002265915,0.0003260944,0.0002040344,0.000119345,0.00007430594,0.0002597805,0.000002275071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001298854,"about_ca_system_score_gemma":0.0001217006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009877583,"about_ca_topic_score_gemma":0.00002366405,"domain_scores_codex":[0.9984686,0.00008638631,0.0004246806,0.0004240651,0.0002439591,0.0003522843],"domain_scores_gemma":[0.9992713,0.00003740725,0.0001318854,0.0003469033,0.00008714517,0.0001252965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001399676,0.0001165594,0.6108648,0.000107464,0.00003199548,0.00002522265,0.00171916,0.00001483524,0.348716,5.614774e-7,0.0008611697,0.03740229],"study_design_scores_gemma":[0.002382398,0.0001931187,0.9139025,0.0003674124,0.00002831484,0.00002906863,0.000331976,0.001395363,0.08092792,0.0001041083,0.0001039809,0.0002338234],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833492,0.01375262,0.001652248,0.0002284429,0.0001928076,0.0006619762,0.000009361864,0.00002724935,0.0001261089],"genre_scores_gemma":[0.9712527,0.004192876,0.02371769,0.0002739899,0.00003851735,0.00002758998,0.00006570519,0.00003949319,0.000391459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3030378,"threshold_uncertainty_score":0.8542197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006073960030228963,"score_gpt":0.1966472596034415,"score_spread":0.1905732995732125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}