{"id":"W2085021556","doi":"10.1016/j.toxlet.2012.08.007","title":"The effect of menadione on glutathione S-transferase A1 (GSTA1): c-Jun N-terminal kinase (JNK) complex dissociation in human colonic adenocarcinoma Caco-2 cells","year":2012,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research; University of Guelph","keywords":"Menadione; Kinase; Chemistry; Cytotoxicity; Reactive oxygen species; Glutathione; Cell biology; Signal transduction; Biochemistry; Oxidative stress; Biology; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000266609,0.0003166192,0.0003960097,0.0002292421,0.0003307182,0.0003943652,0.000253203,0.0003507506,0.002401187],"category_scores_gemma":[0.0001726357,0.0002442761,0.0004458905,0.0003768984,0.0002777115,0.0002999779,0.0002339684,0.0009553541,0.0005298856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006049005,"about_ca_system_score_gemma":0.0005212948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005400073,"about_ca_topic_score_gemma":0.00672135,"domain_scores_codex":[0.9997239,0.00006681282,0.00003693869,0.00004294926,0.00005762564,0.00007175314],"domain_scores_gemma":[0.9998254,0.00004991263,0.00001623716,0.00003509757,0.00002890993,0.00004442227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00234089,0.000182726,0.0005318028,0.0001054548,0.00002091509,0.0001504329,0.000137351,0.0001085329,0.9948144,0.0001353732,0.0001657974,0.001306327],"study_design_scores_gemma":[0.0001221101,0.00118217,0.01153685,0.000007891344,0.00003133231,0.0002083877,0.0002398245,0.0008046619,0.9830483,0.00004794541,0.002756703,0.00001389686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958175,0.001712413,0.0003156032,0.0002742498,0.00008185723,0.00001718869,0.0005670018,0.00002981517,0.00118433],"genre_scores_gemma":[0.9922093,0.0009616715,0.0005318328,0.00008179674,0.00001227229,0.00001997344,0.0009549934,0.000006850318,0.00522122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005400073,"threshold_uncertainty_score":0.01073724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008466913797976509,"score_gpt":0.2544948075907507,"score_spread":0.2460278937927742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}