{"id":"W2085042277","doi":"10.1038/ncomms7351","title":"Epigenetic and transcriptional determinants of the human breast","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"National Institute on Drug Abuse; National Human Genome Research Institute; Kaiser Foundation Research Institute; National Institutes of Health; Genome British Columbia; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre; Natural Sciences and Engineering Research Council of Canada; Johns Hopkins University","keywords":"Epigenomics; Epigenetics; Myoepithelial cell; Biology; Reprogramming; DNA methylation; Cell type; Genetics; Epigenesis; Tiling array; Cellular differentiation; Enhancer; Computational biology; Cell; Transcriptome; Gene; Gene expression; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009394295,0.00005626094,0.00009500409,0.0004020634,0.00009544285,0.0001972025,0.00006062532,0.0001007992,0.001917667],"category_scores_gemma":[0.00022937,0.00008815678,0.00005910034,0.0002983908,0.0001462725,0.00005755936,0.0001313126,0.0001211544,0.0004403325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001571885,"about_ca_system_score_gemma":0.0001194853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001365484,"about_ca_topic_score_gemma":0.002193832,"domain_scores_codex":[0.9999224,0.00001131157,0.000003695785,0.00002746733,0.00002011911,0.00001493344],"domain_scores_gemma":[0.999917,0.00001964523,0.00001912744,0.00001289046,0.00001755869,0.00001387434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002333272,0.00001225808,0.03472835,0.00004515031,0.00001777397,0.0001925821,0.0001712711,0.0001551797,0.9414858,0.0005975988,0.000257605,0.02210317],"study_design_scores_gemma":[0.000005709857,0.0001093685,0.8437839,0.00001715333,0.00003258274,0.002390451,0.0002865057,0.0004307614,0.1400389,0.0007451945,0.01214798,0.00001158125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890484,0.002916822,0.00175213,0.0001426923,0.000007443692,0.00001044907,0.001278835,0.00004560088,0.004797636],"genre_scores_gemma":[0.9954117,0.001362777,0.0006704213,0.00004941409,0.000008892869,0.000007687826,0.0008672079,0.00001109712,0.001610887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001917667,"threshold_uncertainty_score":0.006415188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03069572670230625,"score_gpt":0.3198917726105061,"score_spread":0.2891960459081999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}