{"id":"W2085045501","doi":"10.4161/cc.25268","title":"Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism","year":2013,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Glenn Foundation for Medical Research; Foundation for the National Institutes of Health","keywords":"Biology; Acetylation; Mechanism (biology); Block (permutation group theory); Cell biology; Computational biology; Biochemistry; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150416,0.000395378,0.0004611586,0.0001651462,0.0001445012,0.0001920806,0.0003456188,0.0001821817,0.001782116],"category_scores_gemma":[0.00009086563,0.0001170445,0.0002684406,0.0001019059,0.0002617704,0.0001537854,0.0001341584,0.0007250828,0.000314617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003136721,"about_ca_system_score_gemma":0.0002667745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007293504,"about_ca_topic_score_gemma":0.002563553,"domain_scores_codex":[0.9999071,0.00001651349,0.000007570867,0.00001914849,0.00002386689,0.00002571424],"domain_scores_gemma":[0.9999279,0.00001574448,0.00002665776,0.000007997151,0.000007054158,0.00001466193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003283408,0.0001471883,0.0001933888,0.0000903785,0.000023377,0.00004326028,0.00001113431,0.0002012232,0.9937714,0.0002232423,0.0001361564,0.004830933],"study_design_scores_gemma":[0.0001222613,0.0009166287,0.002457776,0.00000623078,0.00002921485,0.0001525309,0.00001131873,0.0008384464,0.9922546,0.00004251753,0.003161872,0.000006439476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986964,0.006136968,0.003239879,0.0001846438,0.00006591623,0.00005988054,0.0002137569,0.0001512415,0.002983788],"genre_scores_gemma":[0.9927818,0.003049089,0.001803504,0.00009150277,0.00002164379,0.00003550935,0.0003780421,0.00001877926,0.001820184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001782116,"threshold_uncertainty_score":0.005961776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007781093783115832,"score_gpt":0.229987970497266,"score_spread":0.2222068767141501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}