{"id":"W2085045501","doi":"10.4161/cc.25268","title":"Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism","year":2013,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Glenn Foundation for Medical Research; Foundation for the National Institutes of Health","keywords":"Biology; Acetylation; Mechanism (biology); Block (permutation group theory); Cell biology; Computational biology; Biochemistry; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002439168,0.0002320006,0.0003329032,0.0001795019,0.0001617203,0.00004129741,0.0001311768,0.000203098,0.001018893],"category_scores_gemma":[0.00003516031,0.0001822194,0.0001036313,0.0002094995,0.00005643642,0.00017093,0.00005985729,0.0003634079,0.0006875972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001092437,"about_ca_system_score_gemma":0.00006105314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004098891,"about_ca_topic_score_gemma":0.00001551529,"domain_scores_codex":[0.9982555,0.00004869945,0.0003606456,0.0003958503,0.0005153708,0.0004239551],"domain_scores_gemma":[0.9988056,0.00004546328,0.0001076105,0.0004772299,0.0001270199,0.0004370727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002870928,0.0002883762,0.004110001,0.00007953221,0.00004864253,0.00007579099,0.0007130167,0.0001228556,0.9890979,0.00008610797,0.00223757,0.003111515],"study_design_scores_gemma":[0.008161506,0.00186166,0.02247095,0.0003106748,0.0004244707,0.0002364213,0.004012399,0.03198201,0.9235683,0.0020767,0.003943054,0.0009518395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988381,0.0002186119,0.0002486709,0.000810774,0.0008611257,0.0006444338,0.00000172366,0.0001474345,0.008686169],"genre_scores_gemma":[0.9937362,0.0000437365,0.0006621258,0.0006293479,0.001007751,0.0000401847,0.00003762136,0.0000555718,0.003787469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06552957,"threshold_uncertainty_score":0.9998943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007781093783115832,"score_gpt":0.229987970497266,"score_spread":0.2222068767141501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}