{"id":"W2085073963","doi":"10.1016/j.biocel.2008.09.011","title":"Epigenetics and human disease","year":2008,"lang":"en","type":"review","venue":"The International Journal of Biochemistry & Cell Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Genome British Columbia; Michael Smith Health Research BC; Genome Canada","keywords":"Epigenetics; Chromatin; Histone; Biology; Computational biology; Histone-modifying enzymes; Disease; DNA; Epigenomics; DNA replication; Human disease; DNA repair; Genetics; Chromatin remodeling; Bioinformatics; Cell biology; DNA methylation; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008758219,0.0009609812,0.001579722,0.001300331,0.0004768798,0.001156722,0.001065907,0.001694187,0.003406677],"category_scores_gemma":[0.0006102261,0.0003323719,0.0003315102,0.001793148,0.001533908,0.001344985,0.001175842,0.002433301,0.001779553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008178463,"about_ca_system_score_gemma":0.001056998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008375695,"about_ca_topic_score_gemma":0.001705961,"domain_scores_codex":[0.9997783,0.00005342544,0.00002090722,0.00004451695,0.00008193216,0.00002097004],"domain_scores_gemma":[0.999797,0.00008527088,0.00002457059,0.00001555364,0.00005232332,0.0000252334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001068538,0.0000576421,0.0003500643,0.003600226,0.000103416,0.0004691817,0.0001201503,0.0004844912,0.004383579,0.01731722,0.06580265,0.9072045],"study_design_scores_gemma":[0.00002134,0.00003784338,0.0005937851,0.0006106521,0.00004679189,0.00122998,0.00006601484,0.00007687555,0.000645813,0.007844234,0.9888138,0.00001283038],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001499235,0.9950781,0.0004832174,0.001378534,0.001286241,0.000004787766,0.00001372368,0.00001383722,0.001591656],"genre_scores_gemma":[0.001998303,0.9928517,0.0004528719,0.0008842335,0.001673441,0.0000120625,0.00002717286,0.000002114396,0.002098081],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003406677,"threshold_uncertainty_score":0.01139647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02279214210844399,"score_gpt":0.3298578430385771,"score_spread":0.3070657009301331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}