{"id":"W2085073963","doi":"10.1016/j.biocel.2008.09.011","title":"Epigenetics and human disease","year":2008,"lang":"en","type":"review","venue":"The International Journal of Biochemistry & Cell Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Genome British Columbia; Michael Smith Health Research BC; Genome Canada","keywords":"Epigenetics; Chromatin; Histone; Biology; Computational biology; Histone-modifying enzymes; Disease; DNA; Epigenomics; DNA replication; Human disease; DNA repair; Genetics; Chromatin remodeling; Bioinformatics; Cell biology; DNA methylation; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002362388,0.0002942894,0.0004861156,0.00007564072,0.00008471519,0.00003328957,0.0009120086,0.0003280684,0.00002005882],"category_scores_gemma":[0.0001200782,0.0002003824,0.0004054972,0.00004811217,0.000269555,0.000002093887,0.0003007792,0.0002945857,0.00000376412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003759175,"about_ca_system_score_gemma":0.0003621884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004665028,"about_ca_topic_score_gemma":9.171654e-7,"domain_scores_codex":[0.9985296,0.000118432,0.0006956866,0.0002841386,0.0001975482,0.0001746491],"domain_scores_gemma":[0.9982662,0.00006425691,0.0009024536,0.0003299402,0.0002913697,0.000145738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001521257,0.0003372378,0.0004453024,0.001332895,0.001486982,0.000125339,0.00004331418,0.00002348202,0.3580717,0.00007555285,0.00348323,0.6344229],"study_design_scores_gemma":[0.0002242381,0.0001266901,0.00001297136,0.0002893825,0.0001788644,0.0001236417,0.000005823842,8.717777e-7,0.03637967,0.0001467994,0.9622996,0.0002114462],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0148094,0.9838932,0.00008605442,0.00007919507,0.0004398305,0.0001056074,0.00007573106,0.000002560491,0.0005084824],"genre_scores_gemma":[0.01471909,0.9826297,0.0001337394,0.00005556327,0.001558609,0.000005812871,0.0003425606,0.00003103096,0.0005238559],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9588163,"threshold_uncertainty_score":0.8171358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02279214210844399,"score_gpt":0.3298578430385771,"score_spread":0.3070657009301331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}