{"id":"W2085083234","doi":"10.1038/bjp.2008.248","title":"The failure of torcetrapib: what have we learned?","year":2008,"lang":"en","type":"letter","venue":"British Journal of Pharmacology","topic":"Pharmaceutical Economics and Policy","field":"Economics, Econometrics and Finance","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Adverse effect; Cholesterylester transfer protein; Blood pressure; Heart failure; Internal medicine; Aldosterone; Pharmacology; Cardiology; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009528883,0.0009691733,0.003120134,0.0009617735,0.002827576,0.00481826,0.002362949,0.05117496,0.007131179],"category_scores_gemma":[0.05170131,0.0006068046,0.001669699,0.00112952,0.005205327,0.009525045,0.001462575,0.05113354,0.006830764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006029597,"about_ca_system_score_gemma":0.004601445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005012962,"about_ca_topic_score_gemma":0.007486028,"domain_scores_codex":[0.995225,0.001484319,0.0007112032,0.0006886125,0.00143993,0.0004508625],"domain_scores_gemma":[0.9674795,0.02245336,0.001348831,0.001049412,0.004234865,0.003434043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000200977,0.00008385513,0.001186515,0.0002569442,0.00004773399,0.002988236,0.0002094169,0.0001343493,0.0002383922,0.00702981,0.9252267,0.06239702],"study_design_scores_gemma":[0.0002689908,0.0002455403,0.003545123,0.001118014,0.00006652462,0.005056095,0.0007427784,0.0007233002,0.0003205636,0.03793955,0.9498229,0.0001506759],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001896377,0.003021967,0.0000551694,0.9910164,0.005195806,0.000002890518,0.00001909584,0.00001093578,0.0004880507],"genre_scores_gemma":[0.002885737,0.006608382,0.000251243,0.9381216,0.05021944,0.00001742275,0.00002707991,0.00001936292,0.001849834],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05117496,"threshold_uncertainty_score":0.05039418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0595520396669502,"score_gpt":0.2968323390963135,"score_spread":0.2372802994293633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}