{"id":"W2085084256","doi":"10.1016/j.ejmech.2015.01.022","title":"LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153–421): Design, synthesis and biochemical evaluation","year":2015,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital; Health Sciences Centre","funders":"Saudi Arabian Cultural Bureau; Ottawa Hospital Research Institute","keywords":"Kexin; Chemistry; LDL receptor; PCSK9; Proprotein convertase; Reductase; Statin; Cholesterol; Biochemistry; Low-density lipoprotein; HMG-CoA reductase; Enzyme; Pharmacology; Lipoprotein; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006844309,0.0001816196,0.0005904944,0.00005150608,0.00005473581,0.00001323087,0.0001471036,0.0000608337,0.00004437101],"category_scores_gemma":[0.001791647,0.0001411631,0.0001638067,0.00009055417,0.0001868232,0.00007718534,0.00005691274,0.0004254979,0.000002466258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000161421,"about_ca_system_score_gemma":0.000411765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003443944,"about_ca_topic_score_gemma":3.172014e-7,"domain_scores_codex":[0.9972712,0.0005169947,0.0006035448,0.0002218285,0.001189404,0.0001969659],"domain_scores_gemma":[0.9980078,0.0001231746,0.0005853923,0.000310359,0.0004811778,0.0004921266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003801259,0.0001261295,0.000711631,0.0003416753,0.0002760204,0.0003151031,0.000921233,0.000004885541,0.9698376,1.895549e-7,0.0002116804,0.02687373],"study_design_scores_gemma":[0.00353584,0.0004783298,0.01298771,0.001578659,0.0008740313,0.001263119,0.001013372,0.0001223005,0.9778627,0.00006266381,0.00008162238,0.0001396586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943668,0.002464253,0.001364633,0.0003877862,0.00004906159,0.0002047349,0.000003689637,0.00001071637,0.001148285],"genre_scores_gemma":[0.9961252,0.00003821579,0.002802314,0.00003241689,0.0009499684,0.000002445152,0.000006972976,0.00003100291,0.00001152575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02673407,"threshold_uncertainty_score":0.5756463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05408838699581983,"score_gpt":0.2897067651186447,"score_spread":0.2356183781228249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}