{"id":"W2085095087","doi":"10.1074/jbc.m113.537233","title":"Severe Neurodegeneration with Impaired Autophagy Mechanism Triggered by Ostm1 Deficiency","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Neurodegeneration; Osteopetrosis; Microglia; Biology; Autophagy; Cell biology; Astrocyte; Genetically modified mouse; Neuroscience; Transgene; Gliosis; Immunology; Central nervous system; Pathology; Medicine; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307725,0.0005448114,0.0003014352,0.0004111585,0.000190098,0.0001868707,0.0001203891,0.0003326842,0.0006207414],"category_scores_gemma":[0.00007641977,0.000172993,0.000339449,0.000167374,0.0002943924,0.0001365023,0.0002774074,0.0005399841,0.0002177573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00025736,"about_ca_system_score_gemma":0.0002022179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003696092,"about_ca_topic_score_gemma":0.0007360051,"domain_scores_codex":[0.9998804,0.00001590383,0.00001815862,0.00002877453,0.00003440007,0.00002227042],"domain_scores_gemma":[0.9999251,0.000004420614,0.00003719048,0.000005659814,0.000005321195,0.00002226747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001008096,0.00001838785,0.0004740779,0.00003334204,0.000008060892,0.0003929007,0.00001300376,0.00004634535,0.9977221,0.0001054223,0.00004252106,0.001042947],"study_design_scores_gemma":[0.00006094687,0.00055724,0.02653626,0.00002625771,0.00006723941,0.007896315,0.00004287821,0.00113276,0.9591272,0.0003566773,0.00418056,0.00001572913],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940148,0.001492879,0.002963713,0.0001017948,0.00001819911,0.00004448778,0.0004997731,0.0001186151,0.000745693],"genre_scores_gemma":[0.992251,0.001476055,0.003931457,0.00006809495,0.00000925013,0.00006408321,0.0007523653,0.00002065461,0.00142696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006207414,"threshold_uncertainty_score":0.002076626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008036029042839055,"score_gpt":0.2082143136181948,"score_spread":0.2001782845753557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}