{"id":"W2085095087","doi":"10.1074/jbc.m113.537233","title":"Severe Neurodegeneration with Impaired Autophagy Mechanism Triggered by Ostm1 Deficiency","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Neurodegeneration; Osteopetrosis; Microglia; Biology; Autophagy; Cell biology; Astrocyte; Genetically modified mouse; Neuroscience; Transgene; Gliosis; Immunology; Central nervous system; Pathology; Medicine; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002235852,0.0001706865,0.0002444099,0.00001292505,0.00006651055,0.00002837781,0.000220245,0.0001987037,0.00006032119],"category_scores_gemma":[0.0002249341,0.0001080678,0.0001357032,0.00006771891,0.00007410814,0.000006559335,0.00004715506,0.000125211,0.000002155868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007481904,"about_ca_system_score_gemma":0.00007753086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001264232,"about_ca_topic_score_gemma":2.281686e-7,"domain_scores_codex":[0.9989976,0.00007368375,0.0003190998,0.0002395907,0.0001656036,0.0002043658],"domain_scores_gemma":[0.9992005,0.00001865869,0.000275832,0.0001944763,0.000136138,0.0001743637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002189611,0.0001346548,0.0003677016,0.00001438464,0.00001834112,0.000005662236,0.000003770397,0.00002429578,0.9961186,0.00003685357,0.002047913,0.001008869],"study_design_scores_gemma":[0.00104617,0.0006583456,0.001065088,0.000009642055,0.00004147498,0.000239065,0.00002405596,0.00002853314,0.9902661,0.0002658877,0.00615721,0.0001984567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946714,0.001810879,0.002756324,0.00009825921,0.00007245946,0.00004889193,0.00002438096,0.00001034019,0.0005070618],"genre_scores_gemma":[0.9981621,0.0002074155,0.0006382401,0.0002988714,0.0003783234,0.000003090764,0.00006817849,0.00001092774,0.0002328816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005852521,"threshold_uncertainty_score":0.4406877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008036029042839055,"score_gpt":0.2082143136181948,"score_spread":0.2001782845753557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}