{"id":"W2085097639","doi":"10.1016/j.bmcl.2014.11.071","title":"A prodrug strategy for the oral delivery of a poorly soluble HCV NS5B thumb pocket 1 polymerase inhibitor using self-emulsifying drug delivery systems (SEDDS)","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Prodrug; Chemistry; Bioavailability; Pharmacology; In vivo; Drug delivery; Bioconversion; Microsome; Oral administration; Drug; Solubility; In vitro; Chromatography; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001167296,0.0003415956,0.0001954081,0.0001449529,0.0001450244,0.0002177189,0.0002330859,0.0003055909,0.0009954467],"category_scores_gemma":[0.00008983075,0.0001666313,0.0001882135,0.00006808584,0.0001266823,0.0002578581,0.0002243379,0.0004201451,0.0004051331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002567434,"about_ca_system_score_gemma":0.0002036851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004812142,"about_ca_topic_score_gemma":0.000765641,"domain_scores_codex":[0.9999495,0.00000630162,0.000004469591,0.00001408607,0.00001076718,0.00001501393],"domain_scores_gemma":[0.9999784,0.000003345209,0.000006819854,0.000002226168,0.000003524397,0.000005619475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001042889,0.00005208637,0.00004983472,0.00008031468,0.000006124098,0.0001458974,0.00002353058,0.0003166278,0.9844211,0.0006549751,0.0001986151,0.01394646],"study_design_scores_gemma":[0.00004638976,0.0006764631,0.0002276809,0.000005684804,0.00001307161,0.000357991,0.00001055366,0.002080375,0.9917053,0.00006581442,0.004801359,0.000009272291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9114602,0.00399077,0.07393063,0.0005469287,0.0002119014,0.0004567312,0.0003440247,0.0004905513,0.008568428],"genre_scores_gemma":[0.9659135,0.00156619,0.02484476,0.0001600442,0.00001708692,0.00009939721,0.0001667738,0.00002409658,0.007208225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009954467,"threshold_uncertainty_score":0.003330112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03742078827238764,"score_gpt":0.2904736658791129,"score_spread":0.2530528776067252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}