{"id":"W2085151801","doi":"10.1503/cmaj.090199","title":"Personalized medicine: A transformative approach is needed","year":2009,"lang":"en","type":"article","venue":"Canadian Medical Association Journal","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Transformative learning; Personalized medicine; Data science; Precision medicine; Computer science; Engineering ethics; Medicine; Bioinformatics; Psychology; Biology; Pathology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05161362,0.002638693,0.004383121,0.00391085,0.002640399,0.01152929,0.006191675,0.01387235,0.02356651],"category_scores_gemma":[0.06744816,0.0007796945,0.00287121,0.001788215,0.01528727,0.0191083,0.01126552,0.02759156,0.01024602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004810668,"about_ca_system_score_gemma":0.01688119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001671306,"about_ca_topic_score_gemma":0.001617841,"domain_scores_codex":[0.9762475,0.01246733,0.001324007,0.002157302,0.006564906,0.001238886],"domain_scores_gemma":[0.8849571,0.07203724,0.0036932,0.01577502,0.01457356,0.008963916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003401098,0.0008992392,0.002955051,0.004108663,0.001218784,0.0008503038,0.001848339,0.003452729,0.002147071,0.2466997,0.3472522,0.3882279],"study_design_scores_gemma":[0.0001727024,0.0002457478,0.00190198,0.003086933,0.0002713483,0.0009901874,0.002385061,0.001948768,0.0005550223,0.5536027,0.4346547,0.0001847141],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001296015,0.03251366,0.05449834,0.8889618,0.008109641,0.0001982561,0.0002614261,0.0008179609,0.01334288],"genre_scores_gemma":[0.09719086,0.1406805,0.2232546,0.4844657,0.0415538,0.0009991364,0.001148906,0.0005576667,0.0101489],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05161362,"threshold_uncertainty_score":0.2729622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005258176912641314,"score_gpt":0.2244307037031731,"score_spread":0.2191725267905318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}