{"id":"W2085180812","doi":"10.1021/bi034798l","title":"Disease-Causing SAP Mutants Are Defective in Ligand Binding and Protein Folding","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"FYN; Mutant; Cell biology; SH2 domain; Biology; Protein folding; Signal transducing adaptor protein; Mutant protein; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001041351,0.0008824377,0.0002613906,0.0002601143,0.0001539194,0.0002238432,0.0001415951,0.0003359308,0.0009876564],"category_scores_gemma":[0.0002352531,0.0001362706,0.0002116413,0.000138376,0.0002880602,0.0001453171,0.0002551905,0.0002678807,0.0004414191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00012366,"about_ca_system_score_gemma":0.00009122628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001929227,"about_ca_topic_score_gemma":0.0002257346,"domain_scores_codex":[0.9998772,0.00002624827,0.00001534239,0.00001777695,0.00003624165,0.00002712961],"domain_scores_gemma":[0.999835,0.00002620572,0.00005767367,0.00001375434,0.00001322884,0.00005409204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001782714,0.00002677015,0.0009660902,0.00004049974,0.00001170176,0.0009362756,0.0000221461,0.0001544573,0.9955134,0.000130088,0.00007232835,0.001947952],"study_design_scores_gemma":[0.00008459853,0.0009797511,0.0348779,0.00002723335,0.00006684104,0.0203487,0.00009396022,0.003352142,0.9350551,0.000417423,0.004671941,0.00002435397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980924,0.0002689026,0.0009590859,0.00002148233,0.00001184193,0.000008334589,0.0001501771,0.00006139311,0.0004262947],"genre_scores_gemma":[0.9977591,0.0001754108,0.001070599,0.0000169034,0.000006021785,0.000009837642,0.0002754446,0.00002032672,0.0006663114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009876564,"threshold_uncertainty_score":0.003304005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074879280862905,"score_gpt":0.2223431173290475,"score_spread":0.2115943245204184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}