{"id":"W2085181566","doi":"10.1038/onc.2014.41","title":"PKA signaling drives mammary tumorigenesis through Src","year":2014,"lang":"en","type":"article","venue":"Oncogene","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Cure Brain Cancer Foundation","keywords":"Biology; Carcinogenesis; Proto-oncogene tyrosine-protein kinase Src; Cancer research; Signal transduction; Tyrosine kinase; Phosphorylation; Breast cancer; Protein kinase A; Cell biology; Cancer; Internal medicine; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002116819,0.000163684,0.0001507514,0.00003017618,0.0001266378,0.00003241225,0.0001931321,0.0001229437,0.00005510783],"category_scores_gemma":[0.00006163568,0.000160426,0.0001166766,0.00009550985,0.00004447415,0.000007072827,0.00009857379,0.00005159586,0.00003728352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001256851,"about_ca_system_score_gemma":0.00005625531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001087967,"about_ca_topic_score_gemma":0.000004794236,"domain_scores_codex":[0.9989597,0.00008928931,0.0002015595,0.0003559777,0.000150476,0.0002430088],"domain_scores_gemma":[0.9993685,0.00001176441,0.00008424876,0.0003817671,0.00006949378,0.00008415095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001936135,0.0000287151,0.0002071319,0.00001442851,0.00002782633,0.000004151252,0.00002845242,0.0002642187,0.9879956,0.001211638,0.0004094343,0.009788995],"study_design_scores_gemma":[0.0003332886,0.0001004564,0.0001334985,0.00001652954,0.00001353376,0.0000149956,0.0000144681,0.0002286716,0.8619662,0.0007951707,0.1361744,0.0002088506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.762514,0.00284755,0.2249002,0.0003899661,0.0002571509,0.0002217911,0.000009678625,0.00007150418,0.00878823],"genre_scores_gemma":[0.9818427,0.0001321596,0.01561472,0.0006884736,0.0006865236,0.00002304944,0.0001029817,0.00002921275,0.0008801788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2193287,"threshold_uncertainty_score":0.6541983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139216262963872,"score_gpt":0.2464316633472622,"score_spread":0.2350395007176234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}