{"id":"W2085209807","doi":"10.1080/08916930802069256","title":"Active CD4<sup>+</sup>helper T cells directly stimulate CD8<sup>+</sup>cytotoxic T lymphocyte responses in wild-type and MHC II gene knockout C57BL/6 mice and transgenic RIP-mOVA mice expressing islet β-cell ovalbumin antigen leading to diabetes","year":2008,"lang":"en","type":"article","venue":"Autoimmunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute for Health and Care Research; Saskatchewan Health Research Foundation","keywords":"Cytotoxic T cell; Biology; CD8; Interleukin 21; CD80; Major histocompatibility complex; CD40; CTL*; Antigen-presenting cell; T cell; Cell biology; Immune system; Molecular biology; Immunology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0006934754,0.0006924639,0.0009399937,0.0006762068,0.001473546,0.00008049375,0.0004036525,0.0006039656,0.0004108651],"category_scores_gemma":[0.0002759068,0.0006738793,0.0001710379,0.0006721317,0.0004969863,0.0007185278,0.0003464659,0.001089663,0.0003318941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003161757,"about_ca_system_score_gemma":0.0002378635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001021315,"about_ca_topic_score_gemma":0.00001675572,"domain_scores_codex":[0.9957037,0.001458391,0.0008296344,0.0008852923,0.0001230364,0.0009999769],"domain_scores_gemma":[0.9978502,0.0009162892,0.0002578271,0.0006648484,0.000205025,0.000105835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00241972,0.0003643834,0.00103279,0.00006053915,0.0002104154,0.00001854024,0.01854159,0.001440827,0.9716702,0.000001382071,0.0009272874,0.003312383],"study_design_scores_gemma":[0.003711673,0.0007231471,0.00748767,0.000242612,0.0001123039,0.0001681289,0.001800019,0.00143201,0.9563138,0.000006699899,0.02719533,0.0008065831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913931,0.006216165,0.00004199627,0.000171332,0.0007856386,0.0006800194,0.00004991602,0.0001942327,0.000467588],"genre_scores_gemma":[0.9845788,0.001769636,0.0002709841,0.0006029222,0.0000478804,0.0000393345,0.0001540335,0.00009239202,0.01244397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02626804,"threshold_uncertainty_score":0.9998264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931841148331336,"score_gpt":0.2416076026962562,"score_spread":0.2222891912129428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}