{"id":"W2085209807","doi":"10.1080/08916930802069256","title":"Active CD4<sup>+</sup>helper T cells directly stimulate CD8<sup>+</sup>cytotoxic T lymphocyte responses in wild-type and MHC II gene knockout C57BL/6 mice and transgenic RIP-mOVA mice expressing islet β-cell ovalbumin antigen leading to diabetes","year":2008,"lang":"en","type":"article","venue":"Autoimmunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute for Health and Care Research; Saskatchewan Health Research Foundation","keywords":"Cytotoxic T cell; Biology; CD8; Interleukin 21; CD80; Major histocompatibility complex; CD40; CTL*; Antigen-presenting cell; T cell; Cell biology; Immune system; Molecular biology; Immunology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001676121,0.0008098689,0.0002991462,0.0003232041,0.0001058377,0.000336246,0.0002641033,0.0003956961,0.001452335],"category_scores_gemma":[0.0001277563,0.0003170445,0.0002986999,0.00009277389,0.0003733594,0.0002658468,0.0002096117,0.001401715,0.0004904486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002107044,"about_ca_system_score_gemma":0.0001632949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003210623,"about_ca_topic_score_gemma":0.000454057,"domain_scores_codex":[0.9997339,0.00003720667,0.00003528336,0.0000496295,0.00005725039,0.00008684147],"domain_scores_gemma":[0.9996978,0.00003915238,0.00008161441,0.00003031223,0.00002028603,0.0001308767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002688984,0.00004193045,0.0002201728,0.00003509905,0.000003405333,0.00007179022,0.00001224433,0.00003863238,0.998844,0.00004381882,0.00002602573,0.0003940221],"study_design_scores_gemma":[0.00008896997,0.0008180718,0.006637428,0.00001678463,0.00003907284,0.0004728215,0.00005740258,0.0006836461,0.9897652,0.00006480713,0.001348648,0.000007232603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965616,0.0008645326,0.0008979914,0.00009635617,0.00003832834,0.00002255267,0.0002800497,0.00007351968,0.001165055],"genre_scores_gemma":[0.991125,0.0007741351,0.001461053,0.0001491722,0.00003729063,0.0000693817,0.0008119913,0.00005325537,0.005518562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001452335,"threshold_uncertainty_score":0.004858494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931841148331336,"score_gpt":0.2416076026962562,"score_spread":0.2222891912129428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}