{"id":"W2085291344","doi":"10.1007/s00401-008-0395-x","title":"TDP-43-negative FTLD-U is a significant new clinico-pathological subtype of FTLD","year":2008,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Bundesministerium für Bildung und Forschung","keywords":"Frontotemporal lobar degeneration; Pathology; Frontotemporal dementia; Pathological; Dementia; Cytoplasmic inclusion; Biology; Immunohistochemistry; Medicine; Cytoplasm; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005078575,0.0003960487,0.0009570806,0.0001726071,0.0001822358,0.00001776912,0.0005235113,0.0003514602,0.001710946],"category_scores_gemma":[0.002706218,0.000267756,0.0003517318,0.0006590002,0.0008995132,0.00012876,0.0003833816,0.001013838,0.0004056152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006112508,"about_ca_system_score_gemma":0.0003064053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006627966,"about_ca_topic_score_gemma":9.57698e-7,"domain_scores_codex":[0.9960592,0.0005295458,0.0008323628,0.0009480739,0.0008618109,0.0007689395],"domain_scores_gemma":[0.9973155,0.0005706276,0.0003319453,0.0009484612,0.0002961263,0.000537307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002379244,0.001390561,0.1567999,0.00007202924,0.00006402143,0.01088746,0.001676523,0.000003854256,0.7975333,0.0001194677,0.02457365,0.004499995],"study_design_scores_gemma":[0.001953757,0.004505421,0.9718559,0.00006244118,0.00006580451,0.001170846,0.00004940089,0.00006662992,0.01651695,0.0003666868,0.003076539,0.0003096558],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877095,0.0001050867,0.00005184803,0.004947602,0.000161162,0.000738752,0.00003223068,0.0001853003,0.006068582],"genre_scores_gemma":[0.9892288,0.001375818,0.00247731,0.003088894,0.0003504157,0.00002605284,0.00001337136,0.00005189462,0.003387468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8150559,"threshold_uncertainty_score":0.9999775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1292112731266231,"score_gpt":0.3353930797226272,"score_spread":0.2061818065960041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}